A Myc enhancer cluster regulates normal and leukaemic ... - Nature
2018年1月17日 · We propose that clusters of enhancers, such as BENC, form highly combinatorial systems that allow precise control of gene expression across normal cellular …
MYC activity at enhancers drives prognostic transcriptional …
We propose that MYC drives prognostic cancer type-specific gene programs through induction of an enhancer-specific epigenetic switch, which can be targeted by BET and GCN5 inhibitors. …
Regulation of Myc transcription by an enhancer cluster dedicated …
2024年5月10日 · Here we use genomic rearrangements, transgenesis and targeted mutation to analyse Myc regulation in early mouse embryos and pluripotent stem cells. We identify a …
A Myc enhancer cluster regulates normal and leukaemic ... - PubMed
2018年1月25日 · We propose that clusters of enhancers, such as BENC, form highly combinatorial systems that allow precise control of gene expression across normal cellular …
Transcriptional Dysregulation of MYC Reveals Common Enhancer …
2018年4月10日 · Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super …
The MYC enhancer-ome: Long-range transcriptional regulation of MYC
Recent studies have identified a plethora of tissue-specific long-range enhancers of MYC that control its transcription in a tightly regulated-manner. These tissue-specific MYC enhancers …
Nat Genet | 超级增强子介导的基因门控影响癌基因MYC表达
2020年1月2日 · 超级增强子 (Super enhancer, SE) 是一类具有超强转录激活特性的顺式调控元件，2013年由美国学者Richard A. Young首次提出。 近些年来研究发现，超级增强子在癌症发 …
The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC …
However, recent studies have identified numerous tissue-specific noncoding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a …
Myc 增强子簇调节正常和白血病造血干细胞层次,Nature - X-MOL
2018年1月17日 · 转录因子 Myc 对造血干细胞和祖细胞的调节至关重要，并且在造血系统恶性肿瘤中具有关键作用。 在这里，我们展示了位于 Myc 基因下游 1.7 兆碱基处的一个进化保守区 …
Regulation of Myc transcription by an enhancer cluster dedicated …
2024年5月10日 · Deletion of pluripotency-specific enhancers dampens embryonic stem cell competitive ability. These results identify a topologically defined enhancer cluster dedicated to …