Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. It is being used as a vaccine (called MVA-BN, brand names: Imvanex in the EU, [3] Imvamune in Canada, [2] and Jynneos in the US [1]) against smallpox and mpox, [4] having fewer side effects than smallpox vaccines derived from other poxviruses. [5]

mva-bn rsv是一种差异化rsv疫苗，包含5种独特的rsv抗原，以刺激针对全部rsv亚型（a和b）的广泛免疫反应，从而模拟机体对rsv感染产生自然反应后观察到 ...

2024年12月2日 · The vaccine Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) is approved for active immunization against mpox and smallpox. Since the outbreak in 2022, real-world studies have assessed MVA-BN's vaccine effectiveness (VE) against mpox, and this systematic literature review aims to summarize the most current evidence.

2022年11月8日 · MVA-BN RSV是由Bavarian Nordic开发的一种基于MVA-BN载体的疫苗，能够进入哺乳动物细胞，表达病毒蛋白，但是不能复制。 MVA-BN RSV表达5种不同的RSV抗原，能够同时覆盖A型和B型RSV，这也是该产品与其他在研RSV疫苗的不同之处。

2023年6月16日 · The third-generation smallpox vaccine, modified vaccinia Ankara–Bavarian Nordic (MVA-BN), a highly attenuated strain of the poxvirus chorioallantois vaccinia virus Ankara, is licensed for both pre-exposure and post-exposure mpox prophylaxis. 1 MVA-BN has been used extensively as part of the global public health response, and new cases have ...

2024年2月17日 · Our aim was to assess the effectiveness of 1 dose of MVA-BN vaccine as pre-exposure prophylaxis against mpox virus (MPXV) infection in persons on HIV-PrEP. Methods: National retrospective cohort study between 12 July and 12 December 2022. Individuals aged ≥18 years receiving HIV-PrEP as of 12 July with no previous MPXV infection or ...

2019年9月26日 · 丹麦哥本哈根Bavarian Nordic公司宣布，自2018年12月向 美国食品和药物管理局（FDA）提交液体冷冻版MVA-BN的生物制品许可申请非复制型（BLA）的天花疫苗产品（用于18岁及以上成人的主动免疫接种，预防天花）已于今日获得美国FDA批准！同时也是世界上唯一批 …

2022年6月14日 · We have developed an RSV vaccine based on the recombinant Modified Vaccinia Virus Ankara-BN ® (MVA-RSV), containing five RSV-specific antigens that induced antibody and T-cell responses, which is currently tested in clinical trials. Here, the immunological mechanisms of protection were evaluated to determine viral loads in lungs upon ...

2024年5月9日 · Two vaccines, known as MVA-BN and LC16m8, can help prevent mpox. MVA-BN protects animals from lethal doses of mpox and similar viruses. During outbreaks, MVA-BN lowered the chance of mpox disease by 62% to 85%. In people already exposed to mpox, MVA-BN reduced disease risk by 20%.

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