Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These ...

2025年3月30日 · MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC4 include Biliary Tract Cancer and Pancreatic Adenocarcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

该基因编码在细胞表面发现的一种完整的膜糖蛋白，尽管可能存在分泌的同种型。 至少已经发现了该基因的两打转录本变体，尽管其中许多的全长转录本尚未确定，或者它们仅在肿瘤组织中发现。 该基因在编码序列中包含一个区域，该区域具有可变数量 (>100) 的 48 nt 串联重复。 [RefSeq 提供，2008 年 7 月] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins …

MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas.

MUC4 expression is a specific marker of epithelial tumors and its expression correlates positively with the degree of differentiation in several cancers. Importantly, MUC4 has emerged as a specific marker of dysplasia, being expressed in the earliest dysplastic lesions preceding several malignancies …

MUC4 imparting resistance to pancreatic cancer cells against gemcitabine through the activation of anti-apoptotic pathways and, thereby, promoting cell survival. MUC4 is a lineage marker in benign cervical tissue that may have aberrant expression in squamous dysplasia and carcinoma

MUC4 is a transmembrane glycoprotein that functions in cell growth signaling pathways; aberrant MUC4 expression has been reported in various carcinomas. We investigated MUC4 protein expression by immunohistochemistry in LGFMS and in other soft tissue tumors to determine the potential diagnostic use of this novel marker.

2007年6月26日 · MUC4 is a type-1 transmembrane glycoprotein and is overexpressed in many carcinomas. It is a heterodimeric protein of 930 kDa, composed of a mucin-type subunit, MUC4 α, and a membrane-bound...

2021年12月9日 · We developed a method to produce and purify multi-milligram amounts of recombinant MUC4β (rMUC4β). Purified rMUC4β was characterized by Far-UV CD and I-TASSER-based protein structure prediction...

2020年12月4日 · MUC4蛋白是一种跨膜糖蛋白 ，包含一段具有高度等位基因多态性、数目可变的重复序列VNTR，MUC4蛋白能在GDPH位点发生蛋白水解，分解为两个亚基：较大的MUC4α和较小的MUC4β，变成分泌蛋白。 MUC4α包括16个残基序列TSSASTGHATPLPVDT的串联重复结构域，该序列具有七个潜在的糖基化位点。 有研究者发现，用来自MUC4-串联重复区域的糖肽免疫小鼠，能够检测出很强的抗原特异性免疫反应。 抗体滴度和特异性分析的结果提示了糖基化在 …