MTH1酶即MutT同源酶1(MutT homolog 1)，属于Nudix(nucleoside diphosphate linked to x)水解酶超级家族，是由NUDT1基因表达所得的8-羟基鸟嘌呤核苷酸酶，其国际生物化学联合会酶学委员会编号为EC 3.6.1.55。

2-hydroxy-dATP diphosphatase (EC 3.6.1.56, also known as oxidized purine nucleoside triphosphatase, or (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, or Nudix hydrolase 1 (NUDT1), or MutT homolog 1 (MTH1), or 7,8-dihydro-8-oxoguanine triphosphatase) is an enzyme that in humans is encoded by the NUDT1 gene.

2023年8月10日 · Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative...

MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. MTH1 activator-1 can be used to probe the cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis [1] .

2014年4月2日 · We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit...

mth1敲除影响血小板活化后众多蛋白的磷酸化. 为进一步探索mth1对血小板信号通路的影响，研究者进行了定量磷酸化蛋白组学分析，鉴定到多种具有显著差异的磷酸化蛋白，kegg分析发现这些差异的磷酸化蛋白主要富集在血小板活化、mapk和rap1信号通路。

mth1 水平在许多癌症中通常升高，因此，抑制 mth1 是抑制肿瘤生长和转移的一种有吸引力的策略。靶向 mth1 抑制可在癌细胞中诱导 dna 损伤，利用它们对氧化应激的脆弱性并选择性地靶向它们进行破坏。

MTH1 (MutT homolog 1) can effectively sanitize oxidized nucleotides in the nucleotides pool to pro-tect cancer cells from fatal damage caused by high levels of ROS (reactive oxygen species). In con-trast, the normal cells can repair DNA oxidative damage to survive by the alternative pathway when MTH1 is inhibited.

The MTH1 protein functions as an oxidative purine nucleoside triphosphohydrolase and is essential for the protection of cellular nucleotide pools. It catalyzes the hydrolysis of oxidized purine nucleoside triphosphates (such as 2-oxo-dATP and 8-oxo-dGTP), preventing their incorporation into DNA and avoiding base pair transversions.

2023年8月23日 · 本项研究揭示了mth1 对血小板线粒体氧化应激发挥保护作用并参与调控血小板功能和血栓形成，提示mth1 可能是预防血栓性疾病的潜在治疗靶点。 策划 | 党委宣传部