e WT-MSK1-, K455M-MSK1- or D565A-MSK1-expressing SW480 and control cells were seeded onto Matrigel matrix-coated top chambers, and the fold changes of invading cells were measured after 30 h. The ...

2018年10月10日 · Mitogen- and stress-activated kinase 1 (MSK1) is a chromatin kinase that facilitates activator-dependent transcription by altering chromatin structure through histone H3...

2018年1月22日 · We show that MSK1 downregulation impairs the differentiation of breast cancer cells, increasing their bone homing and growth capacities. MSK1 controls the expression of genes required for...

Mitogen- and stress-activated kinase 1 (MSK1) serves as a specific downstream NF-κB RelA/p65 kinase, mediating transcriptional activation of NF-κB-dependent pro-inflammatory genes. The role of MSK1 in nuclear signaling and chromatin modifications is not known, particularly in response to environmental stimuli.

丝裂原和应激激活的蛋白激酶（MSK）是一类核内丝/苏氨酸蛋白激酶，参与丝裂原激活蛋白激酶（MAPK）信号通路介导的下游基因转录调控和表观遗传学调控.首先，MSK是MAPK通路的下游媒介分子.在丝裂原或应激刺激下，p38或ERK激酶通过级联磷酸化激活MSK蛋白.然后，活化的MSK介导转录因子磷酸化活化和组蛋白H3的10位丝氨酸磷酸化.MSK介导的组蛋白H3磷酸化，可引发组蛋白乙酰化和甲基化修...

We have identified a novel mitogen- and stress-activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by ...

Mitogen- and stress-activated kinases (MSK) 1 and 2 are nuclear proteins activated downstream of the ERK1/2 or p38 MAPK pathways. MSKs phosphorylate multiple substrates, including CREB and Histone H3, and their major role is the regulation of ...

The mitogen- and stress-activated kinases-1 and -2 (MSK1 and MSK2) are ubiquitous serine/ threonine kinases that mediate intracellular signal transduction by mitogen-activated protein kinases (MAPKs) of the p38 and ERK1/2 families.

2023年2月23日 · The mitogen- and stress-activated protein kinases (MSK) are epigenetic modifiers that regulate gene expression in normal and disease cell states. MSK1 and 2 are involved in a chain of signal transduction events bringing signals from the external environment of a cell to specific sites in the genome. …

Mitogen- and stress-activated protein kinase (Msk) 1 and Msk2 are nuclear serine/threonine kinases that are widely expressed in tissues including heart, brain, placenta, lung, liver, kidney, and pancreas, with the highest levels observed in brain, muscle, and placenta (Deak et al. 1998).