What is microsatellite instability? - MD Anderson Cancer Center
2023年3月6日 · When you’re diagnosed with cancer, your doctor may refer to whether the cancer has microsatellite instability (MSI). Gastrointestinal medical oncologist and researcher Jason …
肿瘤免疫治疗----先了解下MSI-H/dMMR - 知乎 - 知乎专栏
在2017 年，美国 FDA 首先批准了 PD-1 抑制剂帕博利珠单抗（pembrolizumab，俗称K药）治疗带有微卫星高度不稳定(MSI-H)/错配修复缺陷(dMMR)的实体瘤患者。 代表着肿瘤免疫治疗时代 …
Microsatellite instability - Wikipedia
Microsatellite instability (MSI) is the condition of genetic hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair (MMR). The presence of MSI …
Microsatellite instability: a review of what the oncologist should …
2020年1月13日 · The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI …
60秒dMMR/MSI-H实体瘤简明释义 - 知乎 - 知乎专栏
微卫星不稳定 （microsatellite instability, MSI）最早发现于结直肠癌，目前已知在子宫内膜癌、胃癌、小肠、肝胆系统和结直肠癌等多种相关实体瘤中均涉及 错配修复蛋白 缺失（deficient …
什么是 MSI-H 肿瘤？——自成一派 － 丁香通
2020年6月18日 · MSI-H 肿瘤是指一类具有微卫星高度不稳定（MSI-H）表型的肿瘤，这一概念被收录于美国国家癌症中心（NCI, National Cancer Institute）官方网页的字典中。 MSI-H 的表 …
MMRd, MSI-H, and TMB-H Tumors: What They Are and Why They …
Memorial Sloan Kettering Cancer Center (MSK) is leading the way in developing immunotherapy treatments for cancers with MMRd, MSI-H, or TMB-H. This information explains MMRd, MSI …
Microsatellite Instability in Colorectal Cancer: Overview of Its ...
Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency …
Immunotherapy of MSI Cancer: Facts and Hopes
2024年4月15日 · In this review, we aim to describe the pathogenesis and key immunologic features of dMMR/MSI tumors, provide a brief overview of the currently approved treatments, …
Microsatellite Instability: What Is MSI Testing?
2024年8月1日 · Microsatellite instability occurs when a change happens to the DNA patterns of the microsatellite found within a cancer tumor that are different from what was originally …