2023年11月11日 · PTCHD4-AS enhanced the sensitivity to CDDP by MSH2-MSH6 dimer in GC cells. ( A , B ) Viability of SGC7901 and MGC803 cells stably overexpressing EV or PTCHD4-AS after treatment with the indicated concentrations of CDDP for 24 h.

2014年9月25日 · Mutations are frequently complex MSH2 or MSH6 structural rearrangements rather than MLH1 epigenetic silencing. Our findings identify parallels and differences in the mechanisms of hypermutation...

MSH6, but not MSH2, has a conserved Phe-X-Glu motif that recognizes and binds several different DNA structural distortions, initiating different cellular responses. hMSH6 also contains the nuclear localization sequences required to shuttle hMutSα into the nucleus.

2005年6月10日 · Binding of MSH2-MSH6 to GC base pair substrate DNA in the presence of ADP or ATP results in a low level of bound protein (relative to that seen on GT mispair substrates) that appears to only exhibit end-independent direct dissociation, whereas binding in ATPγS results in low level, stable binding.

1999年9月1日 · In the present study, we demonstrate that MSH2-MSH6-dependent mismatch repair strongly suppresses the rate of G:C-to-T:A transversions in ogg1 mutants and that MSH2–MSH6 specifically recognizes GO:A mispairs and GO:C base pairs.

2016年1月1日 · Resulting uracil-guanine mismatches are processed by uracil DNA glycosylase (UNG)–mediated base-excision repair and MSH2-mediated mismatch repair (MMR) to yield mutations and DNA strand lesions.

2006年10月15日 · We investigated the possible association between gastrointestinal cancer and point variants in exon 7 of the MSH2 gene, especially the substitution of c.1168C>T (p.Leu390Phe). Three-dimensional (3D) protein structures provide valuable insight into the molecular basis of protein function, allowing an effective study of disease-related variants [7].

2006年12月1日 · We have screened germline variations in 101 suspected hereditary GC patients at the coding sequences of MSH2, MLH1, E-cadherin and MYH genes with polymerase chain reaction-denaturing high-performance liquid chromatography …

Microsatellite instability (MSI) is a hallmark of defective DNA mismatch repair (MMR) of genes especially MLH1 and MSH2. It is frequently involved in the carcinogenesis of various tumours including gastric cancer (GC). However, MSI in GCs have not been reported in Malaysia before.

2025年3月30日 · MSH2 (MutS Homolog 2) is a Protein Coding gene. Diseases associated with MSH2 include Lynch Syndrome 1 and Muir-Torre Syndrome. Among its related pathways are DNA repair pathways, full network and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.