MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the …

Jul 15, 2023 · What does an MSH2 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the same …

The MSH2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in …

Mar 24, 2025 · MSH2 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

MSH2 and MSH6 share five similar domains, but with sufficient differences to give MSH6 several distinct functions. MSH6 also has a unique N-terminal disordered domain that is absent in its …

Mar 30, 2025 · MSH2 (MutS Homolog 2) is a Protein Coding gene. Diseases associated with MSH2 include Lynch Syndrome 1 and Muir-Torre Syndrome. Among its related pathways are …

Aug 23, 2022 · Finding out you have an MSH2 gene mutation can be useful information for your family members. It can also help you better understand your cancer risk. Men and women with …

Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pathogenic germline variants in the DNA mismatch repair (MMR) …

Understanding Your Positive MSH2 Genetic Test Result information for patients with a pathogenic or likely pathogenic variant There is a 50/50 random chance to pass on the pathogenic or …

Mar 24, 2025 · MSH2 mutations increase the risk for colorectal, endometrial and other types of cancer listed in the table below. Experts at the National Comprehensive Cancer Network …