2010年11月19日 · We also demonstrate that MSC IDO activity induce the differentiation of monocytes into IL-10 secreting M2 immunosuppressive macrophages (CD14 + /CD206 +). More precisely, tryptophan metabolite kynurenine, derived from the enzymatic activity of IDO induces the conversion of monocytes into M2 macrophages.

2024年11月26日 · Our research reveals IL-10RA as a pharmacological target in stromal cells for enhancing T cell-mediated PDAC eradication by downregulating IDO via blocked IL-10/IL-10RA signalling in MSCs. This...

These IDO-expressing mouse MSC transfectants (MSC-IDO) provide a unique opportunity to study the role of human IDO without interference from iNOS. Since MSCs have been shown to create an immunosuppressive microenvironment and thus promote tumor growth, we examined the effects of MSC-IDO transfectants in the B16-F0 melanoma and EL4 lymphoma ...

2009年5月29日 · Splenocytes stimulated with alloantigen in the presence of the MSC culture supernatant (CS) produced a significant amount of IL-10, which was attributed to an increase in the number of IL-10...

2023年9月23日 · Finally, transplanted CXCL11-IL10-MSCs increased CD19+ and CD4+ lymphoid cells, and decreased CD11b+ Ly6g myeloid cells in an ALI mouse model. These results provide new insights into MSC inflammatory activation and the subsequent translation into a tool for a tailored expression of transgenes in inflammatory microenvironments.

2021年4月9日 · Based on data from this study, we would suggest immortalized MSC-derived EVs enriched with IDO1 as an appropriate candidate in the modulation of immune-related challenges in many scientific or ...

2017年6月23日 · Interleukin (IL)-10 is a contributing factor to neuroprotection of mesenchymal stem cell (MSC) transplantation after ischemic stroke. Our aim was to increase therapeutic effects by combining MSCs and ex vivo IL-10 gene transfer with an adeno-associated virus (AAV) vector using a rat transient middle …

2014年3月1日 · We found that MSC-IDO dramatically reduced both tumor-infiltrating CD8(+) T cells and B cells. Our findings offer an important new line of evidence that interventional targeting of IDO activity could be used to restore tumor immunity in humans, by relieving IDO-mediated immune suppression of MSCs in the tumor microenvironment as well as in ...

In summary, this study suggests that MSCs can control EAE via IDO pathway to promote the proportion and function of CD5+ IL-10+ B cells, providing a promise to treat patients with MS in the clinical setting.

2010年11月19日 · We also demonstrate that MSC IDO activity induce the differentiation of monocytes into IL-10 secreting M2 immunosuppressive macrophages (CD14+/CD206+). More precisely, tryptophan metabolite...