Matrix Metalloproteinases Inhibitors in Cancer Treatment: An …
Matrix metalloproteinases have been linked to a wide variety of pathological states including carcinogenesis. The association between different members of the MMP family and cancer …
Matrix Metalloproteinases in Cancer Cell Invasion - Madame …
Matrix metalloproteinases (MMPs) are a family of secreted, zinc-dependent endopeptidases collectively capable of degrading ECM components, and there is a considerable amount of …
Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning …
DX-2400 is a high-affinity, highly selective inhibitor of MMP-14 that retards tumor growth and metastasis in several in vivo mouse models of breast cancer and melanoma, both as single …
Role of Matrix Metalloproteinases in Angiogenesis and Cancer
2019年12月5日 · MMPs are a family of zinc-binding metalloproteinases that participate in the degradation of ECM components, including the basement membrane and the tumor surface, …
A pan-cancer perspective of matrix metalloproteases (MMP) gene ...
2019年6月14日 · By understanding Matrix Metalloprotease (MMP) dysregulation from a pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple …
Matrix metalloproteinases as breast cancer drivers and therapeutic ...
Members of the matrix metalloproteinase (MMP) family have been identified as poor prognosis markers for breast cancer patients and as drivers of many facets of the tumor phenotype in …
New functions for the matrix metalloproteinases in cancer
2002年3月1日 · Matrix metalloproteinases (MMPs) can regulate the tumour microenvironment, and their expression and activation is increased in almost all human cancers compared with...
Matrix metalloproteinases as therapeutic targets in breast cancer
2023年1月18日 · Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in tumorigenesis. They were initially recognized to promote tumor progression by remodeling …
The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer…
Altered regulation of MMPs can result in various diseases such as cancer, arthritis, nephritis, atherosclerosis, and ulcers [6, 7]. A large body of literature confirmed that in cancer, MMPs …
Strategies for MMP inhibition in cancer: innovations for the
2002年9月1日 · MMPs are involved in the early stages of cancer, explaining the failure of many of the MMPIs in late-stage cancer clinical trials. A greater understanding of the regulatory …