The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the …

Jan 5, 2022 · MHC class I molecules consist of one membrane-spanning α chain produced by MHC genes, and one β chain produced by the β2-microglobulin gene. MHC class II molecules …

MHC class II presents peptide fragments that are generally larger than those presented by MHC class I, because the peptide-binding groove of MHC class II is open, allowing peptides to …

Jul 18, 2013 · Expression of HLA class II molecules is regulated at the transcriptional level by a complex process involving highly conserved sequences, which recruit specific binding factors …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively expressed on the surface of professional antigen-presenting cells (APCs), including dendritic …

Aug 31, 2023 · MHC-I presents epitopes to T8-lymphocytes; MHC-II presents epitopes to T4-lymphocytes. MHC-I molecules are designed to enable the body to recognize infected cells …

Mar 27, 2024 · Both MHC I and MHC II are responsible for distinguishing between self and non-self molecules, allowing the immune system to recognize and eliminate foreign invaders. MHC …

Jan 9, 2025 · Explore the distinct structures, functions, and immune roles of MHC Class I and II molecules in antigen processing and cellular expression.

Mar 12, 2025 · MHC class II is essential for coordinating immune responses against extracellular bacteria and parasites. Pathogens such as Mycobacterium tuberculosis manipulate MHC class …

In this Cell Science at a Glance poster article we will describe the mechanisms that lead to MHC class II trafficking to intracellular sites of foreign-antigen degradation, MHC class II binding to …