The MeCP2 protein binds to forms of DNA that have been methylated. The MeCP2 protein then interacts with other proteins to form a complex that turns off the gene. MeCP2 prefers to bind to sites on the genome with a chemical alteration made to a cytosine (C) when it occurs in a particular DNA sequence, "CpG". This is a form of DNA methylation.

2024年12月25日 · MECP2 (Methyl-CpG Binding Protein 2) is a Protein Coding gene. Diseases associated with MECP2 include Rett Syndrome and Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations. Among its related pathways are Transcriptional Regulation by MECP2 and Gene expression (Transcription).

To demonstrate the current knowledge of the role of such proteins, we have focused our attention on the methylated DNA binding and chromatin-associated protein MeCP2. Structural studies using chromatin assembled in vitro have revealed that MeCP2 can associate with nucleosomes in an N-terminus dependent manner and efficiently condense nucleosome ...

In this review, we will discuss the heuristic evolution of the view of MeCP2, from a single function protein to a multifunctional nuclear protein that directly affects chromatin architecture and is involved with gene expression in unanticipated ways.

Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well-established function in neurodevelopment, as evidenced by the severe ...

2025年3月26日 · Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA.

2020年6月19日 · Our findings indicate that MeCP2 interacts with genomic loci via binding to DNA as well as histones, and that interaction between MeCP2 and histone proteins plays a key role in gene expression...

2024年8月20日 · MeCP2 is a highly disordered and basic protein that exhibits preference for binding methylated cytosines in both CpG and non-CpG contexts but also potently binds unmethylated DNA 11, 12, 13 on...

The MECP2 gene provides instructions for making a protein called MeCP2. This protein helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes.

MECP2 基因突变是大多数 Rett 综合征病例的原因，Rett 综合征是一种进行性神经系统发育障碍，也是女性认知障碍的最常见原因之一。 可变剪接导致编码不同异构体的多个转录变体。