In this review, we will discuss the heuristic evolution of the view of MeCP2, from a single function protein to a multifunctional nuclear protein that directly affects chromatin architecture and is involved with gene expression in unanticipated ways.

2020年2月28日 · Rett syndrome (RTT), a severe postnatal neurodevelopmental disorder, is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is a chromatin organizer...

2024年5月8日 · Fig. 1: MeCP2 localises to DNA-dense foci in mouse cells via its Methyl-DNA Binding Domain (MBD). a Diagram showing the structure of wild-type and mutant MeCP2 constructs (fused with EGFP)...

Schematic illustration of the gene structure of MECP2 and the different domains of the two protein isoforms, MeCP2E1 and MeCP2E2. The primary amino acid composition of the N-terminus of MeCP2E1...

Schematic diagram of (A) MECP2/Mecp2 gene, (B) MECP2E1 and MECP2E2 transcripts, (C) MeCP2E1 and MeCP2E2 isoforms. MeCP2: methyl-CpG binding protein 2. The dark yellow boxes show 5′ and 3′ untranslated regions (UTR). The drawing is not to scale. Information obtained from [12,74,75,77]. Figure is created with BioRender.com.

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the transcriptional...

(A) A schematic diagram of MeCP2 structure with functional domains and three AT-hook domains. Eight common MeCP2 mutations causing RTT and the two mutants discussed by Baker et al. (2013) are...

Diagram illustrating the effects of MeCP2 as a global organizer of chromatin architecture within the nucleus. In this model, loss of MeCP2 in RTT nuclei (right) results in a subtle perturbation of the global chromatin architectural state and a decrease in …

2020年6月16日 · Here, we reveal that MeCP2 can drive the liquid–liquid phase separation (LLPS) in complex with DNA. Interestingly, this ability is compromised in the presence of mutations found in Rett syndrome...

2020年3月13日 · Schematic diagram of mouse MeCP2 protein (e2 isoform) annotated with the activity-dependent phosphorylation sites (above) and other posttranslational modifications (below) found in brain tissue or neuronal/glial cell lines.