Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation …

MDM2 targets p53 for ubiquitination and degradation by the proteasome –, shuttles p53 out of the nucleus,, prevents p53 from interacting with transcriptional co-activators, and recruits …

2009年6月5日 · Recent reports provide novel important insights into Mdm2-mediated regulation of p53 and how the physical and functional interactions between these two proteins are …

In unstressed cells, MDM2 constantly monoubiquitinates p53 and thus is the critical step in mediating its degradation by nuclear and cytoplasmic proteasomes. The interaction between …

2024年5月13日 · Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed to function as a …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important defense …

The R g analysis for the p53, MDM2, and p53–MDM2 complex is given in Figure 7c. Here, we observed the R g values for p53, MDM2, and p53–MDM2 to oscillate within the mean value of …

2020年7月10日 · Targeting the interaction between tumor suppressor p53 and the E3 ligase MDM2 represents an attractive treatment approach for cancers with wild-type or functional TP53.

Mdm2 (murine double minute 2 homolog) is best known for its role as a negative regulator of the tumor-suppressor p53. Due to the ability of p53 to induce cell-cycle arrest and apoptosis, tight …

MDM2 binds the transactivation domain of p53 and inhibits the ability of p53 to activate transcription. Importantly, MDM2 binding also promotes the ubiquitin-mediated degradation of …