Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. Mdm2 is a p53 responsive gene—that is, its transcription can be activated by p53.

2024年12月25日 · MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Transport of the SLBP independent Mature mRNA.

MDM2 is an oncogene that is frequently over-expressed in various human cancers, including sarcomas, gliomas, melanomas, and breast cancers. 1 The primary function of MDM2 is to inhibit the activity of the p53 tumor suppressor protein.

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53, playing a key role in controlling its transcriptional activity, protein stability, and nuclear localization. MDM2 expression is up-regulated in numerous cancers, resulting in a loss of p53-dependent activities, such as apoptosis and cell-cycle arrest.

In humans, the MDM2 gene (also known as HDM2) is located on chromosome 12q14.3-q15 and most frequently expresses a 491 amino acid residue protein. MDM2 is amplified at an overall frequency of 7% in human cancers and at a higher frequency within soft tissue sarcomas, osteosarcomas, and esophageal carcinomas (4, 5).

2024年5月13日 · Studies have shown that in 5.9% of breast cancer patients, the MDM2 gene was amplified approximately 17-fold in tumor cells, and there were post-translational modified MDM2 splice variants. In patients with breast cancer who have alternatively spliced MDM2 transcripts, these variants tend to be more biologically aggressive, with greater ...

2003年12月1日 · Structure of mdm2 gene and protein. mdm2 gene consists of 12 exons and two p53 responsive elements (p53 RE) in intron 1. Two promoters are shown by arrows. Full-length MDM2 p90 is translated from the first start codon ATG in exon 3 and the short form, p76, is translated from the second ATG in exon 4.

The murine double minute 2 (MDM2) gene (also referred to as human double minute 2 (HDM2)) is well recognized for its growth-promoting role in various cancers . The pathogenic role of MDM2 in initiation, progression, metastasis, and chemotherapy resistance of cancer is majorly attributed to gene mutation and deregulated expression [ 2 ].

MDM2 gene amplification as selection tool for innovative targeted approaches in PD-L1 positive or negative muscle-invasive urothelial bladder carcinoma. Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells.

MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53. Polyubiquitylated p53 is rapidly degraded in the cytoplasm by the 26S proteasome. MDM2 is abnormally upregulated in several …