Mdm2 - Wikipedia
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. [5] [6] Mdm2 is an important negative …
杨大俊点评 | 颠覆认知：p53“铁搭档”MDM2，竟是抗癌帮手 - 知乎
MDM2在维持T细胞稳定性、存活和抗肿瘤免疫中发挥着关键生物学作用。 MDM2控制CD8+T细胞介导的抗肿瘤免疫力（来源：Nature Immunology） 具体来说，该研究显示，T细胞MDM2缺 …
MDM2 Gene - GeneCards | MDM2 Protein | MDM2 Antibody
Dec 25, 2024 · MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation. Among its …
MDM2小分子抑制剂的临床研究进展 - 知乎 - 知乎专栏
小鼠双微体2 (Murine double mimute 2, MDM2, 人源为HMD2) 是一种包含RING结构域的 E3泛素连接酶 ，MDM2能够与p53结合，阻断p53结合DNA发挥转录因子活性，促进p53单泛素化而排 …
mdm2癌基因 - 百度百科
mdm2癌基因是1992年才克隆成功的新基因，已在多种肿瘤中发现其突变与扩增，而且mdm2突变与P53突变不共存，mdm2扩增与肿瘤转移密切相关·已有研究表明，MDM2 …
MDM2: RING Finger Protein and Regulator of p53 - Madame …
MDM2 binds the transactivation domain of p53 and inhibits the ability of p53 to activate transcription. Importantly, MDM2 binding also promotes the ubiquitin-mediated degradation of …
Mdm2-mediated ubiquitylation: p53 and beyond - Nature
Jun 5, 2009 · A key Mdm2 function is to promote ubiquitylation and proteasomal-dependent degradation of the tumor suppressor protein p53.
MDM2: current research status and prospects of tumor treatment
May 13, 2024 · This review presents a comprehensive overview of the molecular characteristics of MDM2 and the current state of research on MDM2-targeting inhibitors. It includes a review of …
MDM2功能及其调控机制 - 国际肿瘤学杂志 - Yiigle.com
mdm2是调节p53通路的重要基因,具有降解p53及泛素化的功能,参与肿瘤的发生、发展,并与胚胎发育和组织分化相关.近年来对mdm2的分子作用机制和调控机制的研究取得了一定进展,已 …
MDM2 靶点介绍及实验小贴士 | abcam 中文官网
mdm2 是一种 e3 泛素-蛋白连接酶，参与多种蛋白的泛素化降解途径，比如最主要的功能之一是介导 p53/tp53 的泛素化，导致其被蛋白酶体降解。 mdm2 参与细胞凋亡过程，通过结合其转录 …