Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. [5] [6] Mdm2 is an important negative regulator of the p53 tumor suppressor.

MDM2在维持T细胞稳定性、存活和抗肿瘤免疫中发挥着关键生物学作用。 MDM2控制CD8+T细胞介导的抗肿瘤免疫力（来源：Nature Immunology） 具体来说，该研究显示，T细胞MDM2缺陷小鼠表现出加速的肿瘤进展，且这类小鼠肿瘤浸润CD8+T细胞生存力和功能下降。

2024年12月25日 · MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Transport of the SLBP independent Mature mRNA.

小鼠双微体2 (Murine double mimute 2, MDM2, 人源为HMD2) 是一种包含RING结构域的 E3泛素连接酶 ，MDM2能够与p53结合，阻断p53结合DNA发挥转录因子活性，促进p53单泛素化而排出细胞核或多泛素化而通过蛋白酶体降解，是p53蛋白的负调控因子。几乎所有癌细胞中均存 …

mdm2癌基因是1992年才克隆成功的新基因，已在多种肿瘤中发现其突变与扩增，而且mdm2突变与P53突变不共存，mdm2扩增与肿瘤转移密切相关·已有研究表明，MDM2与MDMX（MDM4）发挥类似抑癌蛋白P53泛素化降解E3作用·因此，mdm2癌基因的变化对阐明肿瘤发病机理以及转移 ...

MDM2 binds the transactivation domain of p53 and inhibits the ability of p53 to activate transcription. Importantly, MDM2 binding also promotes the ubiquitin-mediated degradation of p53, as well as the export of p53 from the nucleus to the cytoplasm.

2009年6月5日 · A key Mdm2 function is to promote ubiquitylation and proteasomal-dependent degradation of the tumor suppressor protein p53.

2024年5月13日 · This review presents a comprehensive overview of the molecular characteristics of MDM2 and the current state of research on MDM2-targeting inhibitors. It includes a review of the impact of MDM2 targeting on the efficacy of immunotherapy, providing guidance and direction for the development of drugs targeting the p53-MDM2 interaction and ...

mdm2是调节p53通路的重要基因,具有降解p53及泛素化的功能,参与肿瘤的发生、发展,并与胚胎发育和组织分化相关.近年来对mdm2的分子作用机制和调控机制的研究取得了一定进展,已用mdm2反义寡核苷酸进行肿瘤的基因治疗.现对mdm2基因的功能及其表达调控机制的研究 ...

mdm2 是一种 e3 泛素-蛋白连接酶，参与多种蛋白的泛素化降解途径，比如最主要的功能之一是介导 p53/tp53 的泛素化，导致其被蛋白酶体降解。 mdm2 参与细胞凋亡过程，通过结合其转录激活域抑制 p53/tp53 和 p73/tp73 介导的细胞周期阻滞和凋亡。