Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [ 5 ] [ 6 ] Northern and western blotting and EST database analyses showed MCT4 to be widely expressed and especially so in glycolytic tissues such as white skeletal muscle fibers, astrocytes , white ...

已发现的mct有14种，其中 mct1 和 mct4 与乳酸代谢关系密切，且倍受运动生理生化界所关注。 MCT1由494个氨基酸构成，贯通12次膜，并有两个末端，即N末端和C末端，C末端的氨基酸排列更具特异性，没有ATP结合部(见图1)。

单羧酸盐转运蛋白4（MCT4）是H +偶联的转运蛋白，在转移性肿瘤和经历缺氧或Warburg效应的炎症部位高表达。 在这些部位，细胞外乳酸有助于恶性肿瘤和免疫应答逃避。

2019年12月27日 · Monocarboxylate transporter 4 (MCT4) is an H +-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and …

2024年11月26日 · mct1 和mct4 是癌细胞中表达最广泛的mct 亚型。mct1 对乳酸的亲和力高，且优先在吸收乳酸的氧化癌细胞中表达[55]。相反，mct4 对乳酸的亲和力低，但周转率高，特别适合促进糖酵解癌细胞输出乳酸，其表达因缺氧而上调，此过程受hif-1α 调节[25]。

近期，一项发表在Cardiovascular Diabetology的研究揭示了单羧酸转运蛋白4（MCT4）依赖性乳酸转运在T2DM心脏能量代谢损伤与炎症中的新颖作用机制，为理解DCM的发病提供了新的视角。 DCM是糖尿病心脏特异性的并发症，表现为心脏结构和功能的改变，最终导致心力衰竭。 尽管已知乳酸作为糖酵解的副产物在T2DM中显著升高，但其在DCM中的具体作用机制尚不清楚。 本研究通过深入探索心肌细胞中的乳酸转运机制，特别是MCT4的作用，为DCM的发病机制提供了新 …

2023年1月27日 · As MCT4 is involved in some of these mechanisms, we hypothesized that MCT4 could be an important target molecule for cancer therapy. Metabolic reprogramming is recognized as one of the...

2025年3月5日 · MCT4 can mediate the metastasis of gastric cancer cells in vivo. Multi-omics analysis showed that the expression of MCT4 was related to the composition of the immune microenvironment, and it could mediate the emergence of the inhibitory immune microenvironment.

作者开发出的新型高效mct4抑制剂可以有效减轻心肌肥大。 作者首先采集了临床中对LVAD应答和无应答患者的左心室组织样本。 分析发现与未发生HF的心脏组织相比，LVAD之前MCP1的表达丰度在两组中都较低。

2018年8月28日 · MCT4 is a H +-linked lactate transporter which functions to facilitate lactate efflux from highly glycolytic cells. High MCT4 levels in HNSCC have been associated with poor prognosis, but the role of MCT4 in the development and progression of this cancer is …