MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif) ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of inflammation, where it attracts or enhances the expression of other inflammatory ...

单核细胞趋化蛋白-1 (monocyte chemotactic protein-1，MCP-1)是β亚家族的代表，可趋化单核细胞。 淋巴细胞趋化蛋白 (lymphotactin)是γ亚家族的代表，对淋巴细胞有趋化作用。 趋化性细胞因子 chemokine是一个蛋白质家族，由十余种结构有较大同源性、分子量多为8～10kD的蛋白组成。

许多研究已经阐明了单核细胞在不同的自身免疫性疾病中募集的分子基础，其结论指出单核细胞趋化蛋白1（mcp-1），也即ccl2及其细胞表面受体ccr2起主要作用。

The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family.

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases.

mcp-1（单核细胞趋化蛋白-1），也称为趋化因子（cc 基序）配体 2 (ccl2)，属于 cc 趋化因子家族。 它在炎症过程中起着至关重要的作用，它吸引或增强其他炎症因子/细胞的表达。

mcp-1 也是一种具有高诊断效果的生物标志物，可以 反映出mtb 感染不同阶段的差异。它也可以通过外 周血中mcp-1 的表达水平诊断和鉴别潜伏性肺结核。 4 mcp-1 在脑部疾病中的作用 mcp-1 可见于ad 的老年斑块和反应性小胶质细 胞中。mci 和轻度ad 患者的血清mcp-1 水平 ...

2010年11月11日 · Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migration.

Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively studied CC chemokine, and the amount of studies on its role in the etiologies of obesity- and diabetes-related diseases have increased exponentially during the past two decades. This review attempted to provide a …

MCP-1 neutralizing Ab (CNTO888) treatment delays tumor growth in an in vivo xenograft mouse model of prostate cancer and inhibits the dissemination of estrogen-dependent breast cancer induced by macrophages in a zebrafish model .