2023年3月13日 · In this study, we demonstrated that circ-Ntrk2 expression is upregulated in hypoxic lung tissues and PASMCs and that its deficiency could improve pulmonary vascular remodelling and relieve PAH via the miR-296-5p/TGF-β1/p38 MAPK signal transduction axis, thus establishing potential targets for PAH diagnosis and treatment. Furthermore, our study ...

2013年11月15日 · Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK

In this study, we included immunocyto- and -histochemical evidence of p38 MAPK activation in human PAH specimens: EC PAH, cells that retain the PAH phenotype in culture, and lung tissue of PAH subjects. Both human specimens exhibited phospho-p38 immunoreactivity and nuclear export of the activated kinase into the cytosol as well as full-length ...

2023年5月1日 · Classic protein kinase pathways inhibit the dedifferentiation and proliferation of PASMCs by mediating the mitogen-activated protein kinase (MAPK), Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), and phosphoinositide 3 …

We developed a computational model of PAAFs mechanosignaling that included TGFβ, MAPK, PDGF, tumor necrosis factor α (TNFα), hypoxia, fibroblast growth factor (FGF), angiotensin II, and Hippo signaling pathways, which are upregulated by PAH, and phenotypic outputs to investigate mechanical regulation of fibrosis in PAH (Wang et al. 2020 ...

2024年4月4日 · CXCR7 expression was upregulated in PAH with activation of MMP2, and inhibition of CXCR7 ameliorated the development of PAH. Our purpose was to determine the possible role of CXCR7 in hypoxia-induced PAH and to clarify how CXCL12/CXCR7 modulates p38 MAPK signaling and MMP2 level in PAH.

Fluoranthene, 1- and 9-methylanthracene induced strong and sustained activation of MAPK ERK1/2, whereas MAPK p38 was activated rather nonspecifically by all tested PAHs. Low/middle MW PAHs can disrupt tissue homeostasis in human airway epithelium via structure-dependent nongenotoxic mechanisms, which can contribute to their human health hazards.

In the systemic vasculature, p38 mitogen-activated protein kinase (MAPK) is part of an important inflammatory pathway. In the pulmonary vasculature, p38 MAPK is a new area of investigation and has been found to contribute to the development of endothelial dysfunction and increased fibroblast proliferation in response to acute and chronic hypoxia.

2013年11月15日 · Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK

2015年4月23日 · In the PAH cells PDGF-BB and FGF2 augment the dysregulated cell proliferation, also through mTOR/6SK. Additionally, blocking the activation of mTOR also modulates the MAP kinase promoted dysregulated growth.