2025年3月30日 · MAP1B (Microtubule Associated Protein 1B) is a Protein Coding gene. Diseases associated with MAP1B include Deafness, Autosomal Dominant 83 and Periventricular Nodular Heterotopia 9. Among its related pathways are Infectious disease and Respiratory Syncytial Virus Infection Pathway.

map1b基因编码微管结合蛋白家族的一个成员，该蛋白在大脑发育过程中对轴突生长和突触成熟很重要。 MAP1B主要表达于神经元体细胞、树突和轴突;在发育过程中，它在轴突生长锥中富集。

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene. [5][6] This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis.

MAP1B, the PCA-2 autoantigen, represents a novel target in paraneoplastic neurological disorders and has high predictive value for SCLC. Its relatively high prevalence, compared with other recognized paraneoplastic neural autoantibodies, justifies its testing in comprehensive paraneoplastic neural a …

The microtubule-associated protein 1B (MAP1B) gene serves an important role in axonal growth and brain development. Its expression is known to be elevated in regions that retain high brain plasticity and is regulated by the fragile X mental retardation protein. MAP1B mutations have recently been ass …

2024年2月22日 · We find that the GSK3β serine/threonine kinase promotes interstitial axon branching in layer 2/3 CPNs by releasing MAP1B-mediated inhibition of axon branching. Further, we find that the tubulin tyrosination cycle is a key downstream component of …

2023年6月26日 · Here, we show that FMRP deficiency leads to elevated microtubule-associated protein 1B (MAP1B) in developing human and non-human primate cortical neurons. Targeted MAP1B gene activation in...

The light chain (LC1) of microtubule-associated protein 1B (MAP1B)-5-HT(3A) receptor interaction contributes to a mechanism that regulates receptor desensitization kinetics. a role for MAP1B in DAPK-1-dependent signaling in autophagy and membrane blebbing. MAP1B action is modulated by mapmodulin/leucine-rich acidic nuclear protein

微管相关蛋白 1b： 该基因编码属于微管相关蛋白家族的蛋白质。该家族的蛋白质被认为参与微管组装，这是神经发生的重要步骤。该基因的产物是一种前体多肽，可能经过蛋白水解加工产生最终的 map1b 重链和 lc1 轻链。

2022年3月24日 · The MAP1B gene encodes a member of the microtubule binding family of proteins that are important for axonal growth and synapse maturation during brain development. MAP1B is primarily expressed in the neuronal soma, dendrites, and axons; it is enriched in the axonal growth cone during development.