M2 macrophages promote tumor progression and therapy resistance, whereas proimmunogenic M1 macrophages can contribute to the efficacy of cytostatic and immunotherapeutic strategies. The abundance of M2 macrophages in the immune infiltrate of many cancer types has prompted the search for strategies t …

2023年9月22日 · M1型与M2型巨噬细胞极化诱导阶段的时程全局定量蛋白质组学研究 接下来，作者对 IL-4 与 IFNγ/LPS 诱导的巨噬细胞极化最初 24 小时内发生的蛋白质组和磷酸蛋白组变化进行了定量时程分析，以确定驱动 M1 型与 M2 型极化的机制。

2022年5月31日 · MAPK regulates three major pathways, including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK (p38), and can differentially alter the phosphorylation...

2019年1月11日 · Together, this study demonstrated that NAR promoted microglia M1/M2 polarization, thus conferring anti-neuroinflammatory effects via the inhibition of MAPK signaling activation. These findings might provide new alternative avenues for neuroinflammation-related disorders treatment.

2020年4月30日 · We examined cytokine secretion, M1 and M2 macrophage-associated marker expression and MAPK phosphorylation levels in AGEs-stimulated macrophages. MIN6 cells were cocultured with AGEs-pretreated macrophages to study the effect of AGEs-induced macrophage activation on β-cell dysfunction.

2025年3月1日 · CHPs drive macrophage polarization toward M1 phenotype. CHPs activate macrophages via MAPK- and NF-κB-dependent pathways. TLR4 mediates the early …

We found that activation of the p38 MAPK pathway in M1 macrophages makes these cells independent of the MEK/ERK pathway and thereby rescues them from death by MEK inhibition, while the survival of M2 macrophages critically depends on the MEK/ERK pathway.

2025年1月1日 · Progranulin inhibit LPS-induced M1 polarization of macrophages via the NF-κB and MAPK pathways (Liu et al., 2020). Various studies suggest that regulating the MAPK signaling pathway can alleviate the inflammatory response caused by M1 macrophages.

p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition. M2 macrophages promote tumor progression and therapy resistance, whereas proimmunogenic M1 macrophages can contribute to the efficacy of cytostatic and immunotherapeutic strategies.

此外，RAW 264 细胞系（来自小鼠腹水的巨噬细胞）用于鉴定 β-榄香烯对抑制细菌内毒素脂多糖 (LPS) 诱导的丝裂原激活蛋白激酶 (MAPK) 途径磷酸化的作用。