Lysosomal damage triggers a p38 MAPK-dependent …
2024年12月16日 · Depletion of HSP27 or the inhibition of HSP27 phosphorylation alters the dynamics of p62 condensates on stressed lysosomes, significantly inhibiting p62-dependent …
Phosphorylation of LAMP2A by p38 MAPK couples ER stress to
2017年11月24日 · ER stressors lead to a PERK-dependent activation and recruitment of MKK4 to lysosomes, activating p38 MAPK at lysosomes. Lysosomal p38 MAPK directly phosphorylates …
Lysosome trafficking is necessary for EGF-driven invasion and …
2017年10月4日 · This study demonstrates for the first time that EGF can stimulate lysosome trafficking to the cell periphery and that EGF-induced lysosome trafficking is necessary for …
Modulating p38 MAPK signaling by proteostasis mechanisms …
2023年7月28日 · Enhancing p38 signaling with caspase cleavage-resistant PMK-1 protects lysosomal and neuronal integrity extending a youthful phase. PMK-1 works through a complex …
快速了解ERK/MAPK信号通路？ - 知乎专栏
丝裂原活化蛋白激酶（mapk）级联是调节细胞多种生理过程的关键信号通路，包括增殖、分化、凋亡和应激反应。 在真核细胞中已经确定了以下四条MAPK级联途径：ERK、JNK、p38 MAPK …
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
2011年6月1日 · Extracellular signal-regulated kinase (ERK) is a mitogen-activated protein kinase (MAPK) that functions as the major effector of the Ras oncoprotein. MAPK pathways consist of …
Lysosomal damage triggers a p38 MAPK-dependent …
2024年12月16日 · Gallagher et al. demonstrate that HSP27 is phosphorylated by a p38 MAPK/MK2 signaling cascade upon lysosomal stress. Phospho-HSP27 is specifically recruited …
Lysosome blockade induces divergent metabolic programs in …
2023年8月4日 · The key mechanisms of lysosome-mediated mucolipin-1(Mcoln1) and mitogen-activated protein kinase (MAPK) activation in M2 macrophage polarization have been …
Lysosomal damage triggers a p38 MAPK-dependent
2024年12月16日 · Depletion of HSP27 or the inhibition of HSP27 phosphorylation alters the dynamics of p62 condensates on stressed lysosomes, significantly inhibiting p62-dependent …
p18/LAMTOR1: a late endosome/lysosome-specific anchor protein ... - PubMed
Activated mTORC1 orchestrates various cellular functions, for example, macromolecule biosynthesis, energy metabolism, autophagy, cell growth, responses to growth factors, and the …