In this study, we analyzed the changes of urinary exosomal lysosome associated proteins in gout patients and evaluated the ability of lysosome associated differentially expressed proteins to monitor acute gout attack, so as to provide a theoretical basis for non-invasive biomarker research for diagnosis and monitoring of acute gout attack.

2025年1月21日 · The urinary exosomes of patients with acute gout attack may exhibit alterations in lysosome-related proteins, particularly CTSZ, AP1B1, and LAMP2, which may become potential biomarkers for monitoring …

1972年1月1日 · This chapter explains the mechanism of lysosomal enzyme release in gout and immunologic tissue injury. The inflammatory episodes of acute gout appear to result from encounters between leucocytes and crystals of monosodium urate (MSU).

2010年4月26日 · The cells most studied in gouty inflammation are leucocytes - in particular, neutrophils and macrophages. Addition of MSU crystals to neutrophils results in cell death and release of lysosomal and cytoplasmic enzymes.

2022年4月22日 · Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1β) release.

2023年4月17日 · Enrichment analysis showed a positive correlation between lysosomal and clinical inflammatory cell shape changes. Untargeted metabolomic analysis revealed that lipids and lipoids accumulate, inhibit autophagic flux, and modulate inflammation and immunity in gouty arthritis patients.

2021年3月3日 · Gout is a common inflammatory arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. This activates the macrophages into a proinflammatory state by inducing NLRP3-dependent interleukin-1β (IL-1β) secretion, resulting in neutrophil recruitment.

IN recent years there has been much interest in the role of crystals in causing acute attacks of gout. Faires and his colleagues at Philadelphia1 and Seegmiller et al. at Bethesda2 were able to produce such attacks by injecting microcrystalline sodium monourate into …

The urinary exosomes of patients with acute gout attack may exhibit alterations in lysosome-related proteins, particu- larly CTSZ, AP1B1, and LAMP2, which may become potential biomarkers for monitoring acute gout attack.

2025年1月21日 · In this study, we analyzed the changes of urinary exosomal lysosome associated proteins in gout patients and evaluated the ability of lysosome associated differentially expressed proteins to monitor acute gout attack, so as to provide a theoretical basis for non-invasive biomarker research for diagnosis and monitoring of acute gout attack.