2025年3月30日 · LYPLAL1 (Lysophospholipase Like 1) is a Protein Coding gene. Diseases associated with LYPLAL1 include Lysosomal Storage Disease. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lysophospholipase activity. An important paralog of this gene is LYPLA2.

Lysophospholipase-like 1 is a protein in humans that is encoded by the LYPLAL1 gene. [1] The protein is a α/β-hydrolase of uncharacterized metabolic function. Genome-wide association studies in humans have linked the gene to fat distribution [2] and waist-to-hip ratio. [3] The protein's enzymatic function is unclear.

2023年10月17日 · 西安交通大学附属第一医院的李磊和美国哈佛大学医学院的魏文毅合作发现，蛋白质LYPLAL1能够导致cGAS去棕榈酰化，从而损伤cGAS的酶活性。 抑制LYPLAL1可以显著增强cGAS介导的免疫反应，提高PD-1抑制剂疗效。 论文首页截图. 研究团队首先发现，cGAS棕榈酰化广泛存在于多种类型肿瘤细胞系中，且实验结果表明，棕榈酰化发生在cGAS的半胱氨酸残基上C404/405位点，是cGAS识别DNA和启动免疫信号通路所必需的。 抑制棕榈酰化可以降 …

2023年10月5日 · We further identified that lysophospholipase-like 1 (LYPLAL1) depalmitoylates cGAS to compromise its normal function. As such, inhibition of LYPLAL1 significantly enhances cGAS-mediated innate immune response, elevates PD-L1 expression, and enhances anti-tumor response to PD-1 blockade.

2023年10月5日 · We further identified that lysophospholipase-like 1 (LYPLAL1) depalmitoylates cGAS to compromise its normal function. As such, inhibition of LYPLAL1 significantly enhances cGAS-mediated innate immune response, elevates PD-L1 expression, and enhances anti-tumor response to PD-1 blockade.

2025年2月8日 · The LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following Roux-en-Y gastric bypass (RYGB) surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success.

2016年7月8日 · We describe the discovery of potent and selective covalent small-molecule inhibitors of LYPLAL1 and their use to investigate its role in hepatic metabolism. In hepatocytes, selective inhibition of LYPLAL1 increased glucose production supporting the inference that LYPLAL1 is a significant actor in hepatic metabolism.

预计可启用羧酸酯水解酶活性和棕榈酰- (蛋白质) 水解酶活性。 预测参与蛋白质脱棕榈酰化。 预计在高尔基体对质膜蛋白转运的负调节上游或负调节中起作用。 位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable carboxylic ester hydrolase activity and palmitoyl- (protein) hydrolase activity. Predicted to be involved in protein depalmitoylation.

2025年2月8日 · Title: Two obesity susceptibility loci in LYPLAL1 and ETV5 independently associated with childhood hypertension in Chinese population. The LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following Roux-en-Y gastric bypass (RYGB) surgery.

Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport and protein depalmitoylation. Located in cytosol. Is expressed in brain and genitourinary system. Orthologous to human LYPLAL1 (lysophospholipase like 1).