2017年8月15日 · Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the...

BCR 聚集后快速激活 Src 家族激酶 Lyn、Blk 和 Fyn，以及酪氨酸激酶 Syk 和 Btk。 这就启动形成一个由 BCR 组成的“信号小体” 、上述酪氨酸激酶、 连接蛋白（如 CD19 和 BLNK），以及信号转导酶，如 PLCγ2、PI3K 和 Vav。

2017年8月15日 · Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the immunoreceptor. By contrast, Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling.

2017年4月3日 · Our data identify Fyn and Lyn as important factors that promote pDC responses, describe the mechanisms involved and highlight a tonic SFK-mediated signalling that precedes pathogen encounter,...

2004年12月2日 · The importance of regulating Lyn activity is exemplified by the pathological conditions that develop in both lyn −/− and lyn gain-of-function mice (lyn up / up), including lethal antibody-mediated autoimmune diseases and myeloid neoplasia. Here, we review the outcomes of altered Lyn activity within the framework of B cell development and ...

根据氨基酸序列， SFK 可分为 2 个亚族：一族为 c-Src 、 Fyn 、 Yes 和 Fgr ，在不同组织中广泛表达；另一族为 Lck 、 Blk 、 Lyn 和 Hck ，与造血细胞密切相关。

2024年4月1日 · Inhibitors of Fyn, Blk, and Lyn kinases show potential for treating disorders that involve abnormal kinase activity. As researchers learn more about complex Fyn, Blk, and Lyn signalling cascades, it is becoming plausible to create compounds that are very good at targeting and blocking specific sites of these kinases.

2017年8月15日 · Src 家族激酶 Fyn 和 Lyn 是 ITAM 抗原受体下游的信号传导成分。 作者在此表明，通过在不同残基处磷酸化 SHP-1，Lyn 和 Fyn 可以对 ITAM 受体产生相反的调节作用。 Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or …

2020年10月10日 · BCR signaling contains two feedback loops from two SFKs: LYN and Fyn. Positive feedback arises from SFK-mediated transphosphorylation of BCR and receptor-bound LYN and Fyn. LYN is considered to be a key factor in regulating B cell homeostasis as the activator or inhibitor of phosphorylation in downstream BCR activation [37, 38].

2023年2月15日 · 近日，北京大学 詹启敏 课题组在 Science China Life Sciences 发表了题为“ Src heterodimerically activates Lyn or Fyn to serve astargets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment” 的研究论文，通过磷酸化组学、转录本芯片技术及临床标本验证， 揭示了Src与SFKs家族成员Fyn及Lyn形成异源二聚体，诱导Fyn及Lyn蛋白结合结构域及激酶结构域中关键酪氨酸的磷酸化激活，进而重塑ESCC细胞中信号网络，介导ESCC细 …