A CD19-Dependent Signaling Pathway Regulates Autoimmunity in Lyn …
2001年9月1日 · CD19 and the Src family protein tyrosine kinases (PTKs) are important regulators of intrinsic signaling thresholds in B cells. Regulation is achieved by cross-talk between Src …
CD19: a biomarker for B cell development, lymphoma diagnosis …
CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B …
Activation and Subsequent Regulatory Roles of Lyn and CD19 …
2002年12月15日 · Despite the apparent opposition of their regulatory functions, a recent model of the biochemical events after B cell receptor (BCR) ligation intimately links the activation of Lyn …
Membrane-associated CD19-LYN complex is an endogenous p53 …
Recent studies indicate that the membrane-associated CD19-Lyn receptor-enzyme complex plays a pivotal role for survival and clonogenicity of immature B-cell precursors from acute …
CD19 Amplification of B Lymphocyte Ca2+ Responses: A ROLE FOR Lyn …
2001年11月30日 · In this study, CD19 engagement using a dimeric anti-CD19 antibody induced [Ca 2+] i mobilization and significantly enhanced BCR-induced [Ca 2+] i responses without a …
CD19 regulates Src family protein tyrosine kinase activation in B ...
CD19 regulates constitutive and antigen receptor-induced signaling thresholds in B lymphocytes through its unique cytoplasmic domain. Herein, we demonstrate a novel molecular mechanism …
A CD19-dependent signaling pathway regulates autoimmunity in Lyn ...
2001年9月1日 · CD19 and the Src family protein tyrosine kinases (PTKs) are important regulators of intrinsic signaling thresholds in B cells. Regulation is achieved by cross-talk between Src …
CD19 Regulates Src Family Protein Tyrosine Kinase Activation …
2000年7月1日 · CD19 regulates constitutive and antigen receptor–induced signaling thresholds in B lymphocytes through its unique cytoplasmic domain. Herein, we demonstrate a novel …
B 细胞受体连接后 Lyn 和 CD19 的激活和随后的调节作用是独立 …
同样，发现 Lyn 的独特功能与 CD19 无关。 CD19-/- B 细胞在 BCR 连接后 Lyn 激酶活性增加、CD22 连接后 BCR 介导的钙通量的抑制以及 FcγRIIB 连接后细胞外信号调节激酶磷酸化的抑制 …
CD19-Dependent Signaling Pathway Regulates Autoimmunity in Lyn ...
2001年9月1日 · CD19 and the Src family protein tyrosine kinases (PTKs) are important regulators of intrinsic signaling thresholds in B cells. Regulation is achieved by cross-talk between Src …