Microbial biosynthesis of designer outer membrane vesicles
2016年10月14日 · Outer membrane vesicles (OMVs) are nanoscale proteoliposomes that are ubiquitously secreted by Gram-negative bacteria. Interest in these bioparticles has escalated …
Meningococcal Outer Membrane Vesicle Composition-Dependent …
In the present study, we have compared the effects of standard OMV isolation methods using detergent or EDTA with those of genetic modifications of LPS to yield a penta-acylated lipid A …
Bacterial outer membrane vesicles engineered with lipidated ... - PNAS
2019年10月7日 · Lipopolysaccharide (LPS) is present in OMVs at a concentration of ∼0.5 mg per milligram of total OMV proteins (14, 26). By binding to TLR4, LPS substantially contributes to …
Bioengineering bacterial outer membrane vesicles as vaccine …
2017年9月1日 · Outer membrane vesicles (OMVs) are naturally non-replicating, highly immunogenic spherical nanoparticles derived from Gram-negative bacteria. OMVs from …
Bacterial Outer Membrane Vesicles as Antibiotic Delivery Vehicles
2021年9月19日 · Bacterial outer membrane vesicles (OMVs) are nanometer-scale, spherical vehicles released by Gram-negative bacteria into their surroundings throughout growth. These …
Neisseria meningitidis - Clinical and Vaccine Immunology
2014年1月29日 · We evaluated the adjuvant effect of a modified glycoform of lipopolysaccharide (LPS) (LgtB-LpxL1) compared to that of the nonmodified glycoform Lpxl1 serogroup B …
Frontiers | Engineered Bacterial Outer Membrane Vesicles as ...
2020年7月9日 · Outer membrane vesicles (OMVs) are valued for their unique, convenient, and amendable functions. They are flexible, controllable nanoparticles, which can be modified in …
Glycoengineered Outer Membrane Vesicles: A Novel Platform for …
2016年4月22日 · Gram-negative bacteria are able to produce outer membrane vesicles (OMVs). OMVs are mainly composed of LPS, outer membrane and periplasmic proteins and …
Effects of Yersinia pseudotuberculosis outer membrane vesicles on ...
2024年12月20日 · Acyltransferases lpxL mutant will cause lower OMVs toxicity. lpxA code UDP-N-acetylglucosamine acyltransferase, but its influence on OMV immune activation is still …
Pushing the envelope: LPS modifications and their consequences
2019年5月29日 · Certain chemical forms of LPS, such as penta-acylated LPS produced by PagL, increase the size and number of OMVs that bacteria release, indicating that LPS modification …