LQVTDSGLYRCVIYHPP (LP17) 是一种髓系细胞表达的触发受体 1 (TREM-1) 抑制肽。 LQVTDSGLYRCVIYHPP 显著减轻缺血诱导的梗死和神经元损伤。 LQVTDSGLYRCVIYHPP …

2019年7月1日 · Accordingly, we tested whether the decoy peptide LP17, a 17-mer peptide sequence of TREM1 in the complementarity-determining region 3 (ref. 43), might attenuate …

In vivo administration of LP17 also showed significant improvement in the treatment of sepsis, rheumatoid arthritis, inflammatory bowel disease, and cancer [46,53]. The conservative …

2020年3月2日 · LPS controls with LP17 peptide treatment resulted in decreased expression levels of the genes of interest, especially IL-6 and CCL7, indicating a successful TREM-1 inhibition …

2016年12月8日 · Blockade of the TREM-1 signaling by a short inhibitory peptide (LP17 and LR12) reduced tissue injury during mesenteric IR and myocardial infarction, emphasizing the …

2024年1月9日 · The ability of actin to activate TREM-1 could be attenuated by treatment with the TREM-1 inhibitor LP17, as well as peritoneal macrophages isolated from Trem1 −/− mice . …

2022年10月22日 · LP17 reduced infarct volume, decreased brain oedema, inhibited microglial activation, and reduced neuronal damage. Both in vivo and in vitro experiments have shown …

In this report, we describe a series of experiments in which we investigated the ability of both full-length and truncated forms of lp17, as well as lp17 gene sequences introduced on a shuttle …

2021年10月12日 · In our study, plasma levels of soluble TREM1 was increased significantly after SAH and correlated to SAH severity and serum C-reactiveprotein. TREM1 inhibitory peptide …

2020年8月27日 · TREM-1 inhibition was determined using its selective inhibitor, LP17, which indicated a neuroprotective effect on cerebral infarction damage. The findings revealed that …