Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain …

里宾斯基五规则（英文：Lipinski's rule of five），也称类药五原则，类药五规则，是辉瑞公司药物化学家 克里斯多夫·里宾斯基 （ 英语 ： Christopher A. Lipinski ） 在1997年提出的筛选类药 …

2016年1月13日 · 1997年辉瑞公司资深药物化学家Lipinski等人、通过对比医药候补分子与通常的有机化合物，得到了成为口服医药小分子化合物应该具有的化学特性，并且归纳为「Rule of five …

类药五原则，是辉瑞公司资深药物化学家Christopher A. Lipinski在1997年提出的筛选类药分子的基本法则，符合Lipinski规则的化合物会有更好的药代动力学性质，在生物体内代谢过程中会有 …

Lipinski's ‘rule of five’ is the first qualitative attempt to guide the design of ‘orally deliverable’ compounds and is based on the limits on properties (clogP, molecular weight and number of …

里宾斯基五规则，也被称为"脂溶性五原则"（Lipinski's Rule of Five）。 这些规则由辉瑞公司资深药物化学家克里斯托弗·里宾斯基（Christopher Lipinski）等人于1997年提出，旨在帮助药物 …

Lipinski's rule of five is a concept frequently used in drug discovery. This rule helps to predict if a biologically active molecule is likely to have the chemical and physical properties to be orally …

In response, Lipinski and coworkers reported an analysis of compounds that successfully navigated Phase I and entered into Phase II clinical studies, and correlated the computed …

“五倍率法则”即“Lipinski五倍率法则”（Lipinski‘s Rule of Five）。 其是评估一个化合物能否作为药物，或者一个具有药理学活性或生物学活性的化合物能否成为口服药物的经验法则。

Lipinski's rule of five also known as the Pfizer's rule of five or Rule of five (RO5) is a rule of thumb to evaluate drug likeness or determine if a chemical compound with a