2025年3月30日 · LIMK2 (LIM Domain Kinase 2) is a Protein Coding gene. Diseases associated with LIMK2 include Williams-Beuren Syndrome and Autism Spectrum Disorder. Among its related pathways are Semaphorin interactions and Signaling by Rho GTPases.

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene. [5][6][7] There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers.

2020年3月1日 · The members of the LIM kinase family of proteins (LIMK1 and 2) regulate actin dynamics by controlling the binding affinity of ADF/cofilin towards actin. LIMK2 has two major splice variants, LMK2a and LIMK2b. We have generated mice lacking LIMK2a expression (LIMK2a KO), to study its specific role in the regulation of the actin cytoskeleton.

2023年7月1日 · LIMK2, a serine-specific kinase, was discovered as an actin dynamics regulating kinase. Emerging studies have shown its pivotal role in numerous human malignancies and neurodevelopmental disorder. Inducible knockdown of LIMK2 fully reverses tumorigenesis, underscoring its potential as a clinical target.

LIM 激酶 1 和 LIM 激酶 2 属于一个小亚家族，具有 2 个 N 末端 LIM 基序和一个 C 末端蛋白激酶结构域的独特组合。 由该基因编码的蛋白质被 Rho 的下游效应子 ROCK 磷酸化和激活，编码的蛋白质反过来磷酸化 cofilin，抑制其肌动蛋白解聚活性。 据认为，该途径有助于 Rho 诱导的肌动蛋白细胞骨架重组。 已为该基因发现至少三种编码不同亚型的转录物变体。 [RefSeq 提供，2008 年 7 月] There are approximately 40 known eukaryotic LIM proteins, so named for the LIM …

LIMK2 is a key regulator that acts through different substrates to provide functional links between the actin cytoskeleton and spindle dynamics. LIMK2 positively regulates the level of Aurora A, thereby engaging in a positive-feedback loop, promoting Aurora-A-mediated oncogenic pathways.

2024年10月23日 · 该研究表明，LIMK2通过增强磷酸化β-连环蛋白（Ser552）和Lrp6信号，促进心肌梗死后肌成纤维细胞增殖和不良心脏重塑。 这提示LIMK2可能是心肌梗死后损伤治疗的一个靶点。

2010年3月1日 · Here, we report the identification of LIMK2, which encodes a kinase that regulates actin dynamics through phosphorylation of cofilin, as a p53 target upregulated by DNA damage. Interestingly, the...

2023年3月4日 · LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. They play a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylati …

2024年7月1日 · LIMK2, a serine-specific kinase, was discovered as an actin dynamics regulating kinase. Emerging studies have shown its pivotal role in numerous human malignancies and neurodevelopmental disorder. Inducible knockdown of LIMK2 fully reverses tumorigenesis, underscoring its potential as a clinical target.