Mar 30, 2025 · LILRB2 (Leukocyte Immunoglobulin Like Receptor B2) is a Protein Coding gene. Diseases associated with LILRB2 include Malaria and Leukemia, Acute Myeloid. Among its related pathways are Innate Immune System and Class I …

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene. [3][4][5] This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4.

OR502通过靶向LILRB2 (ILT4)，调节免疫抑制髓系细胞以恢复先天和适应性免疫反应，并可以逆转抗PD-1治疗的无响应问题。 日前，以LILRB2为代表的LILRB家族已然成为新药研发靶点的新选择。

Jul 22, 2023 · Here, we demonstrate that PirB/LILRB2 regulates the migration of macrophages during NASH by binding with its ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific ANGPTL8 knockout...

LILRB2 blockade reprograms TAMs into a proinflammatory phenotype, suppresses Treg infiltration, and promotes the efficacy of an immune checkpoint inhibitor [168].

抑制性白细胞免疫球蛋白样受体（The leukocyte Ig-like receptor subfamily B LILRB）是一类一次跨膜的糖蛋白，该类蛋白的胞外区有免疫球蛋白类似（Ig-like）的结构域，胞内区域有 ITIM基序 （Immunoreceptor tyrosine-based inhibitory motif 基于酪氨酸的免疫受体抑制性基序）。该家族 ...

IO-108是以明生物自主开发的一款靶向LILRB2的全新抑制性抗体，可以以高亲和力和特异性结合LILRB2，并阻断LILRB2在肿瘤微环境中与癌症免疫抑制相关的配体的相互作用。

Feb 8, 2025 · Mechanistically, LILRB2 enhances the SHP2/CaMK1/CREB signaling pathways to support the expansion and migration of the endometrial cancer cells. LILRB2 is overexpressed in human HCC tissues and is associated with patients' poor survival. LILRB2 may serve as a marker for poor prognosis of HCC.

IO-202是国内首款靶向LILRB4 (ILT3)的单体， 具有较高的结合亲和力和特异性，主要治疗血液瘤（AML和CMML），Immune-Onc同时还在积极计划IO-202在实体瘤中的疗效评估。 Immune-Onc的研发管线聚焦LILRB家族，除IO-202外还有靶向LILRB4的 CAR-T疗法 和双抗在研，另有LILRB2抗体IO-108和LAIR1抗体IO-106。 了解靶点梳理关注微信自媒体药研网. 抗癌新方向，免疫检查点LILRB. 2022年6月，在“Mol Ther Oncolytics”上发表的一篇文章揭示，LILRB在许多癌 …

Jun 18, 2022 · We identified a monoclonal antibody (Ab29) that blocks LILRB2/ligand interactions and prevents TREM2 signaling inhibition mediated by LILRB2. Further, Ab29 enhanced microglia phagocytosis, TREM2 signaling, migration, and cytokine responses to the oAβ-lipoprotein complex in hMGL and microglia cell line HMC3.