Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene. [3][4][5] This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4.

2024年12月25日 · LILRB2 (Leukocyte Immunoglobulin Like Receptor B2) is a Protein Coding gene. Diseases associated with LILRB2 include Malaria and Leukemia, Acute Myeloid. Among its related pathways are Innate Immune System and Class I …

2024年12月19日 · LILRB2 and LILRB4 were demonstrated to be specific biomarkers of chronic lymphocytic leukemia (CLL) and show consistent expression patterns between the two receptors. In one cohort of patients, 6 LILRB2 + patients were uniformly LILRB4 + and 5 LILRB2- patients were uniformly LILRB4- .

We investigated how LILRB targeting could modulate tumor-associated myeloid cell function. LILRB2 antagonism inhibited receptor-mediated activation of SHP1/2 and enhanced proinflammatory responses. LILRB2 antagonism also inhibited AKT and STAT6 activation in the presence of M-CSF and IL-4.

2019年12月15日 · In this study, we characterized LILR binding to the β2-microglobulin (β2m)-free HLA-G1 isoform, which is synthesized by placental trophoblast cells and tends to dimerize and multimerize. The multimerized β2m-free HLA-G1 dimer lacked detectable affinity for LILRB1, but bound strongly to LILRB2.

2021年2月9日 · Here, we review the expression, ligands, signaling, and functions of LILRBs, as well as therapeutic development targeting them. LILRBs may represent attractive targets for cancer treatment, and antagonizing LILRB signaling …

2020年5月12日 · Individual LILR receptors are classified as group 1 (LILRB1, LILRB2, and LILRA1–3) or group 2 (LILRB3–5 and LILRA4–6) members, based on conservation of LILRB1 residues that recognize human leukocyte antigen (HLA) class I molecules (19).

Background: The inhibitory receptor leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2, ILT4), is expressed on immunosuppressive myeloid cells, and has emerged as a key immune checkpoint in the tumor microenvironment (TME).

2025年2月12日 · The present review provides a general overview of the role and mechanisms of LILRB2 in the microenvironment of solid tumors, and emphasizes the significance of targeting LILRB2 as a promising approach for tumor‑specific therapy.

2014年1月30日 · Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All members of LIR subfamily B, such as LILRB2, contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and have an inhibitory function.