2025年3月30日 · LGALS1 (Galectin 1) is a Protein Coding gene. Diseases associated with LGALS1 include Ring Corneal Ulcer and Trophoblastic Neoplasm. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins.

Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. [5][6] LGALS1 contains four exons. The galectin-1 protein is 135 amino acids in length and highly conserved across species. It can be found in the nucleus, the cytoplasm, …

2021年9月1日 · 研究人员鉴定出编码碳水化合物结合蛋白galectin1的LGALS1基因是脑肿瘤干细胞和胶质母细胞瘤抵抗治疗的一个关键调节因子。 LGALS1的基因缺失改变了脑肿瘤干细胞的基因表达谱，导致一组与胶质母细胞瘤的间质亚型相关的基因下调。 2021年9月1日讯/ 生物谷 BIOON/---脑肿瘤 干细胞 （brain tumor stem cell, BTSC）和瘤内异质性是胶质母细胞瘤治疗的主要挑战。 在一项新的研究中，来自加拿大麦吉尔大学的研究人员鉴定出编码碳水化合物结合蛋白galectin1 …

2025年2月8日 · Title: RNA sequencing reveals the transcriptomic landscape and alternative splicing events induced by LGALS1 silencing in non-small cell lung cancer. Galectin-1 Modulates the Fusogenic Activity of Placental Endogenous Retroviral Envelopes.

2024年7月5日 · LGALS1 repression curbed AML progression, lipid accumulation, and CD8 + T and NK cell counts in vivo. Our study sheds light on the roles of LFMRS (especially LGALS1) model in AML, and...

LGALS1 抑制可抑制 AML 进展、脂质积累以及体内 CD8 + T 和 NK 细胞计数。 我们的研究阐明了 LFMRS（特别是 LGALS1）模型在 AML 中的作用，并提供了可能帮助临床医生改善患者预后和制定 AML 个性化治疗方案的信息。 Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance.

半乳糖凝集素是β-半乳糖苷结合蛋白家族，参与调节细胞-细胞和细胞-基质相互作用。 该基因产物可作为调节细胞增殖的自分泌负生长因子。 [RefSeq 提供，2008 年 7 月] The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

The galectin LGALS1 is a glycan binding protein that regulates intracellular (e.g. signal transduction) and extracellular processes (e.g. immunity, leukocyte mobilization) that support cell survival. The protein is best known for its role in RAS signaling. LGALS1 is important in acute lymphoblastic …

2024年12月30日 · 多因素cox回归分析结果显示，ncapg阳性、lgals1阳性是nsclc患者死亡的独立危险因素（p＜0.05）。 结论NCAPG、LGALS1在NSCLC中阳性率升高，与NSCLC肿瘤TNM分期、淋巴结转移有关，是NSCLC患者死亡的危险因素。

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.