Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase. [1][2][3]

Leukotriene modifiers, also called leukotriene receptor antagonists, are a group of medications. They can help prevent breathing problems associated with allergies, asthma and chronic obstructive pulmonary disease.

2024年2月20日 · Leukotriene modifiers work by blocking the action of leukotrienes, one cause of the inflammation and nasal congestion associated with allergies. For those with allergies and asthma, leukotriene...

2023年8月14日 · Leukotrienes (LTs) are a group of inflammatory mediators that belong to the eicosanoid family. Their synthesis, primarily by leukocytes, is spurred by a variety of immunologic and nonimmunologic stimuli, including antigens, immune complexes, complement, cytokines, osmotic challenges, and pollutants, among others.

2020年3月11日 · Leukotrienes are fatty immune system chemicals that come from dietary omega-3 and omega-6 fatty acids. They play a key role in some of the more severe symptoms of allergic rhinitis and...

Leukotriene modifiers prevent the action of leukotrienes in the body. Leukotrienes are substances that are released from mast cells, basophils and eosinophils. These substances cause airway constriction (a narrowing of the airways), increased mucus …

2007年11月1日 · Leukotrienes (“leuko,” from white blood cells; and “trienes,” three conjugated double bonds) comprise a family of products of the 5-lipoxygenase pathway of arachidonic acid metabolism.

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns.

2023年12月7日 · Leukotrienes, derived from arachidonic acid metabolism, exhibit diverse structures, driving their distinct functions. Arachidonic acid serves as their common backbone. Leukotriene A4 (LTA4), a pivotal intermediate, undergoes enzymatic transformations to yield leukotriene B4 (LTB4) and cysteinyl leukotrienes (LTC4, LTD4, LTE4).

Leukotrienes are lipid mediators of inflammation and chemotaxis. As potent bronchoconstrictors they play an important role in mediating immediate hypersensitivity reactions, such as those associated with asthma.