Physiology of leptin: energy homeostasis, neuroendocrine function …
Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues.
Physiology, Leptin - StatPearls - NCBI Bookshelf
2023年4月10日 · Leptin abnormalities have associations with a variety of metabolic syndromes, particularly obesity. The study of leptin physiology has contributed to our understanding of energy homeostasis, and it seems likely that it will play a pivotal role in developing an effective treatment and a solution to the growing obesity epidemic.
Leptin and the endocrine control of energy balance | Nature Metabolism
2019年8月12日 · Secreted by adipose tissue, leptin functions as an afferent signal in a negative feedback loop, acting primarily on neurons in the hypothalamus and regulating feeding and many other functions.
Leptin and Metabolism - Endocrine Society
2020年12月28日 · As a result of its potent metabolic activity, leptin is used to control hyperglycemia in patients with lipodystrophy and is being explored as an adjunct to insulin in patients with type 1 diabetes. To fully understand the role of leptin in physiology and to maximize its therapeutic potential, the mechanisms of leptin action in these tissues ...
The role of leptin in health and disease - PMC
Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts important control on glucose homeostasis, thermogenesis, autonomic nervous system and neuroendocrine axes. In metabolic diseases, such as obesity and ...
Narrative Review: The Role of Leptin in Human Physiology: …
Leptin regulates energy homeostasis, neuroendocrine function, and metabolism. Leptin deficiency is a clinical syndrome associated with distinct phenotypes, which encompass a very small subset of obesity (i.e. those from leptin-related gene mutations), …
Leptin at the Intersection of Neuroendocrinology and Metabolism ...
2013年7月2日 · Since its discovery as an adipocyte-secreted hormone, leptin has been found to impact food intake, energy homeostasis, and metabolism through its effects on the central nervous system and peripheral organs. Recent research indicates that leptin may also be involved in cognition, immune function, and bone metabolism.
Leptin: structure, function and biology - PubMed
Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. Leptin deficiency or resistance can result in profound obesity, diabetes, and infertility in humans. Since its discovery, our understanding of leptin's biological functions has expanded from …
Leptin physiology and pathophysiology in energy homeostasis, …
2024年10月4日 · Leptin is a prototypal adipokine that regulates appetite, neuroendocrine function and metabolism based on energy availability. Through both direct and indirect actions, leptin regulates the hypothalamic-pituitary-gonadal, thyroid, adrenal, and growth hormone axes, differentially between animals and humans.
Leptin physiology and pathophysiology in energy homeostasis, …
We discuss preclinical and human studies describing the pathophysiology of energy deficiency across organ systems and the significant role of leptin in regulating neuroendocrine, immune, reproductive and bone health.
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