Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate.

2024年12月25日 · LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. Diseases associated with LDHA include Fanconi-Bickel Syndrome and Tango2-Related Metabolic Encephalopathy And Arrythmias. Among its related pathways are glycolysis (BioCyc) and Regulation of pyruvate metabolism.

2023年5月1日 · LDHA, LDHB, and LDHC encode for L-isomers of the enzyme, whereas LDHD encodes the D-isomer. The L-isomers use and produce L-lactate, which is the major enantiomeric form of lactate present in the vertebrates.

Lactate dehydrogenase (LDH) is a tetrameric enzyme, belonging to the 2‐hydroxy acid oxidoreductase family, which increases the rate of the simultaneous inter‐conversion of pyruvate to lactate and nicotinamide adenine dinucleotide (NAD)H to …

Lactate dehydrogenase deficiency is a condition that affects how the body breaks down sugar to use as energy in cells, primarily muscle cells. There are two types of this condition: lactate dehydrogenase-A deficiency (sometimes called glycogen storage disease XI) and lactate dehydrogenase-B deficiency.

As an enzyme that catalyzes the final step of glycolysis, lactate dehydrogenase A (LDHA) has become a major focus of research. Here, we have addressed the structure, localization, and biological features of LDHA.

2012年2月1日 · The LDHA gene provides instructions for making a protein called lactate dehydrogenase-A, which is one piece (subunit) of the lactate dehydrogenase enzyme. Learn about this gene and related health conditions.

2018年1月1日 · The LDHA gene encodes the A subunit, which is also often called M subunit, of lactate dehydrogenase, an enzyme which catalyzes the interconversion of pyruvate to lactate and NADH to NAD +. This enzyme was first reported as having five isozymes in 1959, where it was also shown that they were tissue-specific (Markert and Moller 1959 ).

Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research.

2019年3月18日 · Lactate dehydrogenase A (LDHA) is a critical metabolic enzyme belonging to a family of 2-hydroxy acid oxidoreductases that plays a key role in anaerobic metabolism in the cells.

2023年2月1日 · In this review, we introduced lactate dehydrogenase A (LDHA), predominantly involved in glycolysis, which provides energy for T cells and plays a dual role in disease by mediating lactate production, non-classical enzyme activity, and oxidative stress.

Lactate dehydrogenase A (LDHA) is a cytosolic enzyme, predominantly involved in anaerobic and aerobic glycolysis (the Warburg effect); however, it has multiple additional functions in non-neoplastic and neoplastic tissues, which are not commonly known or discussed.

Here, we show that lactate dehydrogenase A (LDHA), a critical glycolytic enzyme, is elevated in the heart in response to hemodynamic stress. Cardiomyocyte-restricted deletion of LDHA leads to defective cardiac hypertrophic growth and heart failure by pressure overload.

LDHA promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma. Knockout of both LDH-A and LDH-B leads to suppression of glycolysis. LDHA and LDHB are dispensable for aerobic glycolysis in neuroblastoma cells while promoting their aggressiveness.

2022年12月1日 · Several genetic and phenotypic studies established the potential role of lactate dehydrogenase A (LDHA) or LDH5, the one homo-tetramer of subunit A, in cancer development and metastasis. The LDHA is considered a viable target for drug design and discovery.

2020年2月28日 · We found that the expression of phosphorylated-PI3K, p-AKT, phosphorylated-mTOR, HIF-1α, LDHA and SIRT6 was significantly higher in tissue from the Atp4a-/- mice compared with the WT mice (P<0.05).

LDHA regulates the microenvironment of developing tumors by the hypoxia-inducible factor (HIF)-signaling pathway. LDHA aids in the NAD + regeneration during the β-oxidation of fatty acid. LDHA (L-lactate dehydrogenase A chain) is responsible for the conversion of pyruvate to lactate, the final step of glycolysis.

LDHA, which is a key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate, is widely overexpressed in a series of cancers including gastric cancer, and the high expression of LDHA in gastric cancer has been associated with shorter overall survival .

Lactate dehydrogenase A (LDHA) is a cytosolic enzyme, predominantly involved in anaerobic and aerobic glycolysis (the Warburg effect); however, it has multiple additional functions in non-neoplastic and neoplastic tissues, which are not commonly known or discussed.

2024年5月24日 · The IHC results showed lactate dehydrogenase A (LDHA) conversion of pyruvate to lactate in both the entire nerve section and intraneural blood vessels had increased (Fig. S3D–3 F), whereas pyruvate dehydrogenase-E1-alpha subunit (PDH-E1α) conversion of pyruvate to acetyl-CoA had decreased (Fig. S3G–I).

我们发现磷酸化pi3k，p-akt，磷酸化mtor，hif-1α，与野生型小鼠相比，atp4a-/-小鼠的组织中的ldha和sirt6显着更高（p <0.05）。 H +，K + -ATPaseα亚基是体内壁细胞的酸分泌活性，胃黏膜的正常发育和细胞稳态以及分泌膜正常结构所必需的。