In this review, the current evidence for the function of each LAMP2 isoform in various pathophysiological processes and human diseases, as well as their possible mechanisms, are comprehensively summarized. We discuss the evolutionary patterns of the three isoforms in vertebrates and provide technical guidance on investigating these isoforms.

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins.

溶酶体相关膜蛋白 2 （lysosome-associated membrane glycoprotein 2， LAMP2）是溶酶体上含量丰富的一种膜蛋白，对溶酶体结构和功能的维持均起到重要作用。 LAMP2基因突变最初被发现与一种叫做 达农病 （Danon病）的X连锁显性遗传病有关，该病以致命的肥厚性心肌病、骨骼肌病和智力残疾为临床特征，病理特征为骨骼肌、心肌和神经组织中大量自噬空泡积聚。 2000年，LAMP2敲基因成功构建，该小鼠展现出与达农病相似的特征，如自噬空泡在全身多种组织 …

2022年3月25日 · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a process that is dependent on the membrane protein LAMP2A. Moreover, we demonstrate that this mechanism is independent of the ESCRT machinery but dependent on HSC70, CD63, Alix, Syntenin-1, Rab31, and ceramides.

In this review, the current evidence for the function of each LAMP2 isoform in various pathophysiological processes and human diseases, as well as their possible mechanisms, are comprehensively summarized. We discuss the evolutionary patterns of the three isoforms in vertebrates and provide technical guidance on investigating these isoforms.

We report the isolation and characterization of the murine homologues to human and chicken lysosome-associated membrane protein (Lamp)-2 transcripts and their prevalent expression patterns during development. Lamp-2 transcripts code for proteins predominant in and specific for the lysosomal membrane …

LAMP2A is one of three isoforms of the gene lamp2, encoded through alternative splicing and the only isoform involved in CMA. All LAMP2 isoforms are lysosomal transmembrane proteins, and what differentiates LAMP2A from LAMP2B and LAMP2C are regions within the transmembrane domain and cytosolic tail.

关于 lamp2 Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,426,148-120,469,349 (from NCBI) This gene has 4 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 4 phenotypes.

Enables protein domain specific binding activity. Involved in several processes, including autophagosome maturation; protein stabilization; and protein targeting to lysosome involved in chaperone-mediated Autophagy. Acts upstream of or within muscle cell cellular homeostasis.

In this review, the current evidence for the function of each LAMP2 isoform in various pathophysiological processes and human diseases, as well as their possible mechanisms, are comprehensively summarized. We discuss the evolutionary patterns of the three isoforms in vertebrates and provide technical guidance on investigating these isoforms.