The left anterior descending artery (LAD, or anterior descending branch), also called anterior interventricular artery (IVA, or anterior interventricular branch of left coronary artery) [1] is a branch of the left coronary artery. It supplies the anterior portion of the left ventricle. [2] .

Our study reveals how NAT machineries have divergently evolved to N-terminally acetylate specific subsets of target proteins. Subject terms: Enzyme mechanisms, Acetylation, X-ray crystallography. The conserved eukaryotic heterotrimeric NatC complex co-translationally acetylates the N-termini of numerous target proteins.

2015年2月11日 · LAD stands for left anterior descending artery. It is a coronary artery, which is the name given to arteries that supply the heart muscle with blood. The LAD is considered the most important of the three main coronary arteries and is almost always the largest.

A NatC complex construct (designated NatC WT), expressing the truncated NatC subunits Naa30 C17 Δ (residues 1 –159), full-length Naa35 (residues 1 –733), and Naa38 ΔC11 (residues

2023年10月30日 · The left anterior descending artery, preferably known as the anterior interventricular artery (AIV), or LAD artery, is the continuing branch of the left coronary artery. It is located subepicardially within the anterior and inferior interventricular sulci of the heart.

2021年10月7日 · NatC is an unusual member of protein N-terminal acetyltransferases in requiring a small Naa38 subunit for activity. Deng et al. finds that Naa38 is required for normal NatC acetylation, inositol hexaphosphate binding contributes to yeast NatC complex stability, and NatC adopts a unique NAT architecture with a distinct substrate profile.

Here, we present the crystal structure of the Saccharomyces cerevisiae NatC complex, which exhibits a strikingly different architecture compared to previously described N-terminal acetyltransferase (NAT) complexes.

Deng et al. finds that Naa38 is required for normal NatC acetylation, inositol hexaphosphate binding contributes to yeast NatC complex stability, and NatC adopts a unique NAT architecture with a distinct substrate profile. Protein N-terminal acetylation is predominantly a ribosome-associated modification, with NatA-E serving as the major enzymes.

2022年8月4日 · What is the left anterior descending (LAD) artery? Your left anterior descending (LAD) artery is one of two branches of your left main coronary artery. Anterior means the artery supplies blood to the front portion of your heart. It's the biggest supplier of oxygenated blood to your heart’s lower left pumping chamber or ventricle.

2025年2月22日 · The left anterior descending (LAD) artery, also known as the anterior interventricular branch, is one of the two branches of the left coronary artery (the other branch being the circumflex (Cx) artery).