β-Lactam antibiotics are bactericidal agents that interrupt bacterial cell-wall formation as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in the terminal steps of peptidoglycan cross-linking in …

A lactam is a cyclic amide, which is derived from an amino alkanoic acid. The term is a portmanteau of the words acetone + amide. Lactams form by the acid-catalysed rearrangement of oximes in the Beckmann rearrangement.

β-Lactam or azetidin-2-one is an important structural motif of the penicillin, cephalosporin, carbapenem and carbecephem classes of antibiotics. 1 Naturally occurring as well as synthetic monobactams, such as nocardicins and tabtoxin, are also known for their unique antibacterial activities. 2–4 Besides their importance as the key structural ...

Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes.

A lactam is a cyclic amide, which can be found in different forms: α-lactam (three-atom rings), β-lactam (four-atom rings), γ-lactam (five-atom rings), δ-lactam (six-atom rings), and ɛ-lactam (seven-atom rings). From: Green Approaches in Medicinal Chemistry for …

Rather than an active-site serine, these enzymes employ a hydroxide that is activated by coordination to the Zn(II) ion(s) as the nucleophile initiating β-lactam hydrolysis.

2023年12月6日 · Lactam rings are found in many biologically active natural products and pharmaceuticals, including important classes of antibiotics.

2024年9月30日 · Lactam antibiotics are essential in modern medicine. Lactams, particularly β-lactams like penicillin and cephalosporins, inhibit bacterial cell wall synthesis by targeting peptidoglycan. The …

Lactam | C14H17NO3 | CID 53982816 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

The amino group at one end reacts with the carboxylic acid group at the other, closing the molecule to form the ring. This kind of ring is called a lactam. The type of lactam is designated by using a Greek letter prefix that indicating the number …