The role of LXRs in regulating target gene expression in the absence of ligand is unknown. Here we show that LXRs interact with corepressors, N-CoR (nuclear receptor corepressor) and …

ChIP analysis of the ABCA1 promoter suggests that the recruitment of corepressors is largely mediated by LXR and that agonist binding or genetic deletion of LXR induces corepressor …

We provide several independent lines of evidence indicating that the repressive actions of LXRs are dependent on interactions with the nuclear receptor corepressor (NCoR) and the silencing …

2003年6月1日 · These experiments establish that LXR LBDs interact with corepressors in mammalian two-hybrid assay and repress transcription when fused to a GAL4 DBD in the …

Within the nucleus, LXR/RXR heterodimers are bound to LXREs in the promoters of target genes and in complex with corepressors (e.g., smrt, n-cor). In response to the binding of oxysterol …

In the absence of ligands, LXR/RXR heterodimers form complexes with classic nuclear receptor corepressors to inhibit the transcriptional activity of target genes. However, in the presence of …

In the presence of ligands (Fig. 1C), LXR undergoes a conformational change that induces release of corepressors, recruitment of specific coactivators and, subsequently, transcription of …

2023年2月2日 · Here, we review the development of LXR inverse agonists that were originally optimized for their ability to enable recruitment of corepressors leading to silencing of genes …

Unliganded LXR associated with corepressors, including nuclear receptor corepressor (NCoR)/silencing mediator of retinoic acid and thyroid receptor (SMRT), recruits histone …

2020年8月1日 · Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be pharmacologically activated by high-affinity agonists. LXR activation exerts a …