表皮生长因子受体 （Epidermal Growth Factor Receptor, EGFR）是一种跨膜受体酪氨酸激酶，参与调节巨噬细胞 LPS /TLR4信号传导 [3]。 唐靖 课题组前期研究也发现，EGFR磷酸化协同TLR4调节 内毒素血症 中巨噬细胞的激活 [4]。 然而，作为膜受体分子，EGFR在巨噬细胞极化中的细胞内运输过程及其对细胞能量代谢的作用仍不清楚。

2022年11月7日 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for EEA1-mediated the...

Epidermal growth factor receptor (EGFR) activation prevents experimental NEC and may play a critical role in LPS-stimulated COX-2 production. We hypothesized that EGFR is required for LPS induction of COX-2 expression. Our data show that inhibiting EGFR kinase activity blocks LPS-induced COX-2 expression in small intestinal epithelial cells.

2010年5月24日 · Epiregulin (EPI) and amphiregulin (AR) are epidermal growth factor receptor (EGFR) ligands implicated in mucosal repair and tumorigenesis. We have shown that Toll-like receptor 4 (TLR4) induces...

Increasing evidences demonstrate that EGFR regulates LPS-induced and TLR4-mediated inflammatory response. Lu et al. found that LPS stimulated EGFR activation in macrophages, which regulated cytokine production and experimental colitis .

The present study revealed inhibition of LPS-induced vascular cell adhesion molecule-1 expression by HGF via the degradation of EGFR. We demonstrated that HGF regulated Src homology domain 2-containing inositol 5'-phosphatase 2 recruitment to EGFR and inhibited LPS-induced inflammation via EGFR degr …

Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for EEA1mediated the membrane translocation of EGFR from the Golgi. On the other hand, EGFR phosphorylation prevents its endocytosis in a kinase activity-dependent manner.

In bone marrow-derived macrophages (BMDM), we observed LPS-induced EGFR phosphorylation on the surface of BMDM, and this was inhibited by pretreatment with PD168393 or TAPI-1 (Fig. S1). Next, we measured dynamic changes in …

2013年8月20日 · LPS promoted EGFR activation, and inhibiting EGFR activation by AG1478 significantly decreased LPS-induced MUC5AC overexpression in HIBECs. Moreover, LPS increased TGF- α secretion, and inhibiting tumor necrosis factor- α converting enzyme (TACE), which has been implicated in ectodomain cleavage of TGF- α , significantly inhibited LPS ...

2015年4月27日 · Our results suggest that EGFR is essential for LPS-induced, TLR4/MyD88-mediated NRas activation and induction of a robust proinflammatory cholangiocyte response. These findings have implications not only for revealing the signaling potential of TLRs, but also implicate EGFR as an integral component of cholangiocyte TLR-induced proinflammatory ...