The Lockheed P-38 Lightning is an American single-seat, twin piston-engined fighter aircraft that was used during World War II. Developed for the United States Army Air Corps (USAAC) by the Lockheed Corporation, the P-38 incorporated a distinctive twin-boom design with a central nacelle containing the cockpit and armament.

5 天之前 · Phospho-p38 MAPK (Thr180/Tyr182) Antibody detects endogenous levels of p38 MAPK only when activated by phosphorylation at threonine 180 and tyrosine 182. This antibody does not cross-react with the phosphorylated forms of either p42/44 MAPK or SAPK/JNK. It will also react with p38 singly phosphorylated at Thr180 and singly phosphorylated at Tyr182.

2004年1月8日 · 丝裂原活化蛋白激酶 (mitogen-activated protein kinase,MAPK)转导通路调节着生长、分化、凋亡、细胞周期、应激反应等多种细胞过程.p38通路是新近鉴定的一条MAPK信号转导通路,参与了炎症、应激、细胞周期和凋亡等病理生理过程.蛋白激酶特定的细胞内定位及其在特定 ...

LPS induced a significant increase in p38 phosphorylation after 15 min of treatment (p b 0.01) ( Fig. 2A & B). LPS also caused a rapid (15 min), transient and robust increase in JNK ...

The LPS-mediated suppression of SOD in the rat BALF was prevented by treatment with colchicine. Treatment of the rats with colchicine attenuated the LPS-induced activation of P-38, Erk1/2, and JNK in pulmonary tissues.

TLR4 was effectively silenced as determined by Western blot and TLR4 siRNA suppressed the activation of p38 MAPK and NF-κB pathways in OSCC cell lines treated with LPS. G. NF-κB-dependent...

2019年1月15日 · Plasmalogens (Pls) can inhibit NO production in microglial cells. Pls inhibit NF-kB, p38MAPK and JNK pathways. The special lipids plasmalogens (Pls) were reported to be reduced in the neurodegenerative brains such as Alzheimer’s disease where a marked increase of glial activation is often observed.

2020年7月7日 · Here, we show that p38IP suppresses T‐cell receptor (TCR)/LPS‐activated NF‐κB and p38 by targeting TAK1 kinase and that p38IP protein levels are downregulated in human PBMCs from rheumatoid arthritis (RA) patients, inversely correlating with the enhanced activity of …

2021年6月3日 · The effect of celastrol on bone marrow-derived macrophages (BMDMs) after LPS treatment was measured by ELISA and Western blotting. Results In vivo, celastrol reduced the …

2024年2月1日 · LPS increases TRAF6/LRRK2 interaction through activation of TLR in human lymphoblastoid cells, leading to increased phosphorylation levels of p38 MAPK and IκBα, thereby increasing TNF release [83].