2017年6月13日 · Here we show that Escherichia coli LPS (0111:B4; 10–25 μg/ml), but not phorbol myristate acetate (PMA), activates JNK in human neutrophils in a dose-dependent manner. JNK inhibitors SP600125...

本研究采用lps诱导小鼠心肌细胞凋亡，通过检测相关凋亡因子表达水平及其在心肌组织中的浸润情况，阐明aps通过抑制nf-κb和jnk信号通路减轻lps诱导的小鼠心肌细胞凋亡。

2018年1月11日 · Our results showed that LPS treatment potentiated the phosphorylation of JNK, p38 and ERK, which is consistent with studies showing that LPS affected MAPK signaling pathways in other cell...

In the present study, prolonged LPS exposure increased both total JNK expression and JNK phosphorylation in the hypothalamus, whereas acute LPS treatment increased only Phospho-c-Jun N-terminal Kinase (pJNK) expression (Figure 2C,D).

在我们之前的研究中，我们发现 LPS 通过激活丝裂原活化蛋白激酶 (MAPKs) 途径，如 c-Jun N 端激酶 (JNK) 和细胞外信号调节激酶 (ERK1/2) 来促进破骨细胞分化和活性。

2017年6月13日 · JNK inhibitors SP600125 and TCSJNK6o, and a TLR4 inhibitor TAK242 suppress reactive oxygen species production and NETosis in LPS-, but not PMA-treated neutrophils. Diphenyleneiodonium suppresses LPS-induced NETosis, confirming that endotoxin induces NADPH oxidase-dependent NETosis.

方法 在正常的和基因敲减mGluR5的小胶质细胞中,用脂多糖 (LPS)建立炎症模型,通过Griess实验、酶联免疫吸附试验、免疫印迹法、流式细胞术等方法,探测CHPG对LPS诱导的炎症反应,mGluR5表达及其下游MAPKs信号分子活性的影响. 结果 LPS诱导炎症反应,引起mGluR5表达量下降,下游JNK活性下降,CHPG逆转上述过程 (P =0.0003, P =0.005).在mGluR5敲减的细胞中,CHPG作用消失 (P =0.4694, P =0.4407). 结论 激活mGluR5抑制炎症反应是通过上调该受体表达量及其下游 …

2021年11月13日 · LPS promotes JNK signaling pathway activation and endogenous TNF-α secretion in pulmonary macrophages, which could facilitate lung fibroblasts aerobic glycolysis and lactate production through...

2002年11月15日 · To delineate the mechanism underlying LPS-induced CD44 expression, we investigated the role of the mitogen-activated protein kinases (MAPKs), p38, p42/44 extracellular signal-regulated kinase, and c-Jun N-terminal kinase (JNK) by using their specific inhibitors.

The MAPK signaling pathway was blocked by pretreatment with JNK inhibitor SP600125. LPS treatment induced a significant decrease in cell metabolism, viability, and ALP activity in MC3T3-E1 cells. LPS also significantly decreased mRNA expressions of osteoblast-related genes in MC3T3-E1 cells.