2019年8月15日 · In BV2 cells, 6KApoEp reduced TNFα secretion more effectively than 6DApoEp and ApoEp, which was blocked by PCSK9 treatment, suggesting a role for LDL receptors. 6KApoEp also inhibited LPS-induced p44/42 MAPK, JAK2 and STAT3 phosphorylation, while enhancing p38 MAPK phosphorylation.

2013年4月8日 · ApoA-I potently suppresses LPS-induced atherosclerosis by inhibiting the inflammatory response possibly via activation of STAT3 and upregulation of TTP.

We determined the anti-inflammatory effects of novel apoE receptor mimetics, composed of the LDL receptor-binding domain of apoE (aa 133-152, ApoEp) or ApoEp with 6 lysines (6KApoEp) or 6 aspartates added at the N-terminus (6DApoEp).

ApoA-I protects from sepsis by binding to and neutralizing lipopolysaccharide (LPS) and lipoteichoic acid (LTA), components of the Gram-negative and Gram-positive bacterial cell wall, respectively [33,34].

ApoA-I potently suppresses LPS-induced atherosclerosis by inhibiting the inflammatory response possibly via activation of STAT3 and upregulation of TTP.

2006年6月6日 · High density lipoprotein (HDL) binds lipopolysaccharide (LPS) and neutralizes its toxicity. The aim of our study was to investigate the effects of Apolipoprotein (ApoA-I), the major apolipoprotein of HDL, on LPS-induced acute lung injury (ALI) and endotoxemia. BALB/c mice were challenged with LPS, f …

目的:本项目拟通过建立内毒素血症小鼠模型,探讨ApoA-I对LPS诱导的内毒素血症的治疗作用及可能机制. 方法:以小鼠内毒素血症模型为研究对象,小鼠被随机分为生理盐水组,ApoA-I低剂量组 (10mg/kg),ApoA-I高剂量组 (50mg/kg),LPS组 (LPS+D-半乳糖),D-半乳糖组 (生理盐水+D-半乳糖).建立小鼠内毒素血症模型;以放射免疫分析药盒测定血浆中细胞因子TNF-α,IL-6和IL-8的浓度;取小鼠肝组织和肺组织做病理切片,观察组织病理变化;RT-PCR法检测小鼠不同组织中LPS受体CD14 …

2024年2月1日 · We established LPS-induced endothelial dysfunction models in both cultured bovine aortic endothelial cells (BAECs) and mouse models to determine the effects of 3′-SL. Western blotting, qRT-PCR analysis, immunofluorescence staining, and en face staining were employed to clarify underlying mechanisms.

2010年10月24日 · We show that human apo A–I gene transfer decreases TLR4 expression in vivo in the absence of LPS and attenuates TLR4 signalling following LPS administration. Similar effects on TLR4 expression and TLR4-mediated signalling were induced by HDL in human microvascular endothelial cells (HMEC)-1 in vitro.

To investigate the effects of the major component of high-density lipoprotein apolipoprotein A-I (apoA-I) on the development of atherosclerosis in LPS-challenged ApoE −/− mice and the underlying mechanisms. Male ApoE-KO mice were daily injected with LPS (25 μg, sc) or …