Pan-Caspase Inhibitor zVAD Induces Necroptotic and Autophagic …
2022年4月30日 · In macrophages, necroptosis can be induced by co-treatment with Toll-like receptor (TLR) ligands (lipopolysaccharide [LPS] for TLR4 and polyinosinic-polycytidylic acid …
ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM ...
2021年1月4日 · Furthermore, we show that constitutive binding between ZBP1 and RIPK1 is essential for the initiation of TRIFosome interactions, caspase-8-mediated cell death and …
MLKL, the Protein that Mediates Necroptosis, Also Regulates …
2017年7月18日 · Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed …
Caspase抑制剂Z-VAD-FMK通过诱导巨噬细胞坏死病和促进MDSCs …
在这里，我们发现用zVAD治疗小鼠可以显着降低脂多糖（LPS）攻击后的死亡率并减轻疾病。 值得注意的是，在LPS攻击的小鼠中，zVAD治疗还可以通过促进坏死性坏死和抑制巨噬细胞的 …
Vemurafenib inhibits necroptosis in normal and pathological …
2023年8月24日 · Previous studies have revealed that lipopolysaccharide (LPS) can induce necroptosis of intraperitoneal macrophages in the presence of z-VAD, whereas genetic …
Low doses of LPS exacerbate the inflammatory response and
2018年5月2日 · We stimulated human blood monocytes with agonists for TLR4 (LPS), TLR3 (poly (I:C)) and TLR7/8 (R848) and subsequently challenged them to low doses of endotoxin. The …
Cell Death Dis | 公共卫生学院王慧等联合团队发现新型细胞程序性 …
2023年9月9日 · 本研究基于老药新用的研究策略，对FDA批准上市的药物库进行筛选，发现抗癌药物维罗非尼可以作为一种有效的程序性坏死抑制剂。 通过直接结合受体相互作用蛋白激 …
The Caspase Inhibitor Z-VAD-FMK Alleviates Endotoxic Shock via …
2019年8月2日 · Here, we found that treatment of mice with zVAD could significantly reduce mortality and alleviate disease after lipopolysaccharide (LPS) challenge. Notably, in LPS …
ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM ...
2021年1月4日 · Furthermore, we show that constitutive binding between ZBP1 and RIPK1 is essential for the initiation of TRIFosome interactions, caspase-8-mediated cell death and …
Autophagy Contributes to Caspase-independent Macrophage …
Autophagy was induced in macrophages treated with lipopolysaccharides (LPSs) and the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp (Z-VAD), and the inhibition of autophagy by …