2025年3月18日 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe inflammatory diseases. Lipopolysaccharide (LPS), a pivotal pathogen-associated molecular pattern (PAMP) on the surface of gram-negative bacteria, is recognized by Toll-like receptor 4 (TLR4), initiating a complex cascade of immune ...

研 究显示，TLR4 能通过直接识别包括 LPS，脂磷壁酸（lipoteichoic acid，LTA），dsRNA 等在内的 病原相关分子模式 （pathogen associated molecular pattern，PAMP）而在激 活天然免疫过程中起到关键作用。近年来，该分子在引起炎症反应，抗病毒感染， 肿瘤治疗和调节免疫应答 ...

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR …

2013年12月6日 · The common structural pattern of LPS in diverse bacterial species is recognized by a cascade of LPS receptors and accessory proteins, LPS binding protein (LBP), CD14 and the Toll-like...

TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling cascades: the first one involving TIRAP and MyD88 adaptor proteins is induced in the plasma membrane, whereas the second engaging adaptor proteins TRAM and TRIF begins in early endosomes after endocytosis of the receptor.

TLR4 has now been established as the receptor for LPS; however, in addition to this, TLR4 also recognizes lipoteichoic acid (LTA), fibronectin, the fusion protein of respiratory syncytial virus (RSV) and taxol, a plant diterpene structurally unrelated to LPS but exhibiting LPS-mimetic effects on murine cells. 8, 17, 22 – 24 The evidence that ...

2024年3月13日 · 原因可能在于tlr4的拷贝数太低，或者是lps和tlr4的亲和力太低；相比之下，cd14 的数量以及同lps的亲和力均高出许多。 另一个设想是在CD14与TLR4之间存在一个蛋白水解系统将双方联系起来。

LPS的生理作用是通过存在于宿主细胞的细胞膜表面的 Toll样受体 （Toll-like Receptor、TRL）4（TRL4）而体现的。 1997年，Medzitov等在《Nature》报道人类存在与果蝇Toll受体同源的Toll蛋白，在激活获得性免疫中起 信号转导 作用。

Toll-like receptor 4 (TLR4) is critical for activation of macrophages by Lipopolysaccharide (LPS). In this study, we investigated the silencing effects of TLR4-specific 21-nt small interfering RNAs (siRNA) on TLR4 expression in RAW264.7 cells. It was found that treatment with TLR4 siRNA down-regulated the TLR4 mRNA and protein expression in …

4 天之前 · Toll-like receptor 4 (TLR4) is an innate immune receptor that detects the endotoxin lipopolysaccharide (LPS) from gram-negative bacteria and plays a crucial role in the pathogenesis of sepsis 10 ...