poly (I:C) and LPS induce distinct IRF3 and NF-kappaB ... - PubMed
The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used to study type-I IFN and TNF responses in human macrophages. Additionally, …
IRF3 regulates neuroinflammatory responses and the expression …
2024年8月30日 · Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine …
Inflammation causes insulin resistance in mice via interferon ...
2024年5月30日 · Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous …
Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB ...
2018年2月5日 · By combining stochastic mathematical modelling and experimentation, we demonstrate that feedback interactions between the IRF3, NF-κB and STAT pathways lead to …
IRFs: master regulators of signalling by Toll-like receptors and ...
2006年9月1日 · In addition to IRF3 and IRF7, induction of the nitric-oxide synthase 2 (Nos2) gene, an event that is crucial for antibacterial responses, depends on IRF1 in LPS- and IFNγ (type II...
STING-IRF3 contributes to lipopolysaccharide-induced cardiac ... - PubMed
In vitro experiments revealed that NLRP3 overexpression by adenovirus could offset protective effects of STING knockdown in LPS-induced cardiomyocytes. Additionally, LPS stimulation …
Lipopolysaccharide-mediated Interferon Regulatory Factor …
TANK Is Involved in the LPS-mediated IRF3/7-activating Pathway—To demonstrate the existence of an endogenous, signal-responsive TANK-containing protein complex that phosphorylates …
STING-IRF3 contributes to lipopolysaccharide-induced cardiac ...
2019年6月1日 · In wild type mice and cardiomyocytes, LPS stimulation triggered the perinuclear translocation of STING, which further bound to Type-I interferons (IFN) regulatory factor 3 …
Essential role of IRF-3 in lipopolysaccharide-induced ... - PubMed
2003年7月11日 · Using IRF-3 deficient mice, we show here that IRF-3 is indeed essential for the LPS-mediated IFN-beta gene induction. Loss of IRF-3 also affects the expression of profile of …
Essential role of IRF-3 in lipopolysaccharide-induced interferon-β …
2003年7月11日 · In the present study, we used mice deficient in the IRF-3 gene (IRF-3 −/− mice) and determined how the loss of IRF-3 affects the LPS-induced gene induction events in the …