Phosphatidylserine (PS) is a negatively charged molecule. The amount of the negative zeta potential in the liposomes depends on the molar percentage of the phosphatidylserine (PS) in the formulation. The matrix lipid, DOPC, that is used in the formulations does not significantly contribute to the charge of the liposomes.

Trehalose is used as a lyoprotectant in all freeze-dried liposome formulation. The size distribution after hydration of the freeze-dried formulation will be around 100 nm. Freeze-dried liposomes should be kept at -20°C. Lyophosome™ is a white lyophilized powder.

To investigate the effect of IL-6 on the production of NO upon stimulation with LPS agonists, RAW264.7 cells were stimulated with LPS, 506, or GLA-60 in the presence of anti-mouse IL-6 antibody, and the amounts of NO in the culture supernatant were measured. In addition, the activities of TNF-α and IL-6 in the culture supernatant were determined.

When administered to mice systemically or via the airways, LPS induces bronchoconstriction (BC) and/or bronchopulmonary hyperreactivity (BHR), associated to inflammation. Accordingly, a relation between inflammation and allergic and non-allergic BHR can be hypothesized.

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It was found that miR-506 was upregulated following LPS treatment in DPSCs. The inhibition of miR-506 in LPS-treated DPSCs led to attenuated inflammation and deactivation of the TLR4 pathway. Furthermore, the bioinformatic analysis and dual-luciferase reporter gene assay indicated that miR-506 could target the 3′-UTR of sirtuin 1 (SIRT1).

Lyophilized liposomes product series are freeze-dried liposomes with various types of lipids and wide range of zeta potentials and different properties. These products should be used by …

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Product Number : LPS-501, LPS-502, LPS-503, LPS-504, LPS-505, LPS-506, LPS-507, LPS-508, LPS-509, LPS-510, LPS-511, LPS-512, LPS-513 Brand : LYOPHOSOME™ Company Address : ENCAPSULA NANOSCIENCES LLC 5409 MARYLAND WAY, SUITE 360 BRENTWOOD, TN, 37027 Technical Phone : 615-884-4442 Fax : 615-250-8747 ...