LPS is a known activator of T cell immunity and epithelial to mesenchymal transition (EMT). In the airways, these processes have been shown to potentiate lung fibrosis and are increased in lung transplant recipients (LTRs) with chronic lung allograft dysfunction (CLAD).

脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。

2020年1月7日 · While TLR4 was thought to be the only sensor for LPS, recent studies have provided insight into two TLR4-independent LPS recognition systems: transient receptor potential (TRP) channel-dependent sensing of extracellular LPS and caspase-4/5/11-dependent sensing of intracellular LPS.

2020年1月7日 · Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-studied pathogen-associated molecular pattern. A component of Gram-negative bacteria, extracellular LPS is sensed by our immune system via the toll-like receptor (TLR)-4.

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2016年11月1日 · HBU-379 was generated by hybridizing Trm with propazylated acetyl-syringic acid. HBU-376 and HBU-375 dose-dependently inhibited LPS and caused nitric oxide (NO) generation in BV2 cells, whereas HBU-379 minimally inhibited NO generation, indicating that the paeonol unit plays an important role in the anti-inflammatory effect of Trm hybrid compounds.

2016年7月12日 · In this study, an aptasensor assay based on hybridization chain reaction (HCR) was developed to detect LPS. Briefly, two complementary stable species of biotinylated DNA hairpins coexisted in...

脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的重要成分，对细菌的生存和致病性具有重要影响。 LPS位于细菌外膜的外层，在无荚膜菌株中直接暴露在细胞表面。

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Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate immune-activating stimuli known. Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal transduction with attention given to receptor …